Lupus Nephritis Susceptibility Genes Identified Interview with:

Dr. David W. Powell PhD
Associate Director of Clinical Proteomics
Assistant Professor of Medicine Assistant
Professor of Biochemistry and Molecular Biology
Department of Medicine/Nephrology
570 South Preston Street Baxter Research Building I, Room 102 South
Louisville, Kentucky What are the main findings of the study? 

Dr. Powell: We found a strong association for variants in the gene encoding ABIN1 (a physiologic inhibitor of NF-B) and nephritis in systemic lupus erythematosus patients and that mice expressing a loss of function mutation of ABIN1 develop pathophysiologic features of the most common and severe form of human lupus nephritis.

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