27 Aug Lupus Nephritis Susceptibility Genes Identified
Hemodialysis.com Interview with:
Dr. David W. Powell PhD
Associate Director of Clinical Proteomics
Assistant Professor of Medicine Assistant
Professor of Biochemistry and Molecular Biology
Department of Medicine/Nephrology
570 South Preston Street Baxter Research Building I, Room 102 South
Hemodialysis.com: What are the main findings of the study?
Dr. Powell: We found a strong association for variants in the gene encoding ABIN1 (a physiologic inhibitor of NF-B) and nephritis in systemic lupus erythematosus patients and that mice expressing a loss of function mutation of ABIN1 develop pathophysiologic features of the most common and severe form of human lupus nephritis.
Last Updated on August 27, 2013 by Marie Benz MD FAAD