Byproduct of Sweet Potato Waste Offers Clue To Lipid Metabolism Interview with:
Dr. Koji Ishiguro

National Agriculture and Food Research Organization
Japan What is the background for this study?

Response: -Sweet potato (Ipomoea batatas L.) roots are not only used for human consumption, they are used to make starch materials, processed foods, and distilled spirits in Japan. Starch use accounts for about 15% (131,500 tons) of total sweet potato production. Starch residues are discharged during starch production and are mainly used in animal feed and compost. Large amounts of the wastewater, which can cause serious environmental problems, are discarded after clarification. Investigation into the uses of the by-products of the sweet potato starch industry would benefit both the environment and industry. What are the main findings?

Response: We prepared sweetpotato peptide (SPP) by enzyme digestion of sweet potato protein from starch wastewater. Sweet potato peptide (SPP) diet lowered abdominal adipose tissue mass, serum cholesterol in VLDL and LDL and triglyceride levels, and serum leptin levels in mice fed a high-fat diet. Biomarker arrays indicated that adiponectin, melanocyte-stimulating-hormone-alpha and neuromedin U levels were higher and TNF-alpha levels were lower in the livers of SPP-administered mice. What should readers take away from your report?

Response: The by-products of food industry can be used effectively. What recommendations do you have for future research as a result of this study?

Response: Next step of this study is to develop the large-scale production system of sweetpotato peptide and to confirm the effect of SPP administration on the disorder of lipid metabolism in human. Is there anything else you would like to add?

Response: The effect of SPP on lipid metabolism is not for human but for mice in this study. This is the limitation of our findings so far. Take care not to overinterpret. Thank you for your contribution to the community.


Koji Ishiguro, Rie Kurata, Yoshikazu Shimada, Yoto Sameshima, Takashi Kume. Effects of a sweetpotato protein digest on lipid metabolism in mice administered a high-fat diet. Heliyon, 2016; 2 (12): e00201 DOI: 10.1016/j.heliyon.2016.e00201

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