Severe Periodontitis Associated with Insulin Resistance Interview with:

In-Seok Song, DDS, PhD Clinical Assistant Professor Oral and Maxillofacial Surgeon Department of Dentistry, Korea University Anam Hospital, Seoul, Republic of Korea


In-Seok Song, DDS, PhD
Clinical Assistant Professor
Oral and Maxillofacial Surgeon
Department of Dentistry, Korea University Anam Hospital,
Seoul, Republic of Korea What is the background for this study? What are the main findings?

Response: Periodontitis is a well-known cause of various systemic diseases including cardiovascular disease, type 2 diabetes. As for type 2 diabetes, insulin resistance is responsible for the low-grade systemic inflammation, which can deteriorate body function throughout pancreatic β-cell dysfunction and impaired fasting glucose. There are emerging evidences that insulin resistance is a cause of periodontal disease progression among Korean adults as well as other citizens including American, French, Finnish, and the British.

In this study, we hypothesized that insulin resistance aggravates the severity of periodontitis. We investigated the associations between type 2 diabetes, insulin resistance, and severe periodontitis. The associations between severe periodontitis and insulin resistance in non-obese adults with normal body mass index (BMI) or waist circumference (WC) were also evaluated.

We found that non-abdominal obese adults with insulin resistance were more likely to have severe periodontitis compared to metabolically healthy adults with normal waist circumference. Insulin resistance without abdominal obesity can be considered an independent risk factor of severe periodontitis. What should readers take away from your report?

Response: Healthcare workers including dental practitioners and physicians should be aware that metabolically obese subjects even with normal waist circumference need lifestyle modifications to reduce their risk of type 2 diabetes and chronic periodontitis. Physical activity and toothbrushing instruction are required to reduce the aggravating interaction between these diseases. What recommendations do you have for future research as a result of this study?

Response: Further randomized clinical trial or longitudinal large-sample based cohorts are required to clarify the exact causal relationship among type 2 diabetes, unhealthy metabolic status, and severe periodontitis. Is there anything else you would like to add?

Response: The poor oral health of your mouth is closed linked to various systemic diseases, which can deplete quality of life, increase risks of morbidity and mortality. Therefore, more attention and supporting systems from the government to elucidate the associations between oral health problems and systemic diseases are required to improve citizens’ general health as well as oral health. Thank you for your contribution to the community.

Severe Periodontitis is Associated with Insulin Resistance in Non-Abdominal Obese Adults In-Seok Song, DDS, MSD, PhD1 , Kyungdo Han, PhD2 , Yong-Moon Park, MD, MS, PhD3 , Suk Ji, DDS, MSD, PhD4 , Sang Ho Jun, DDS, MSD, PhD1 , Jae-Jun Ryu, DDS, MSD, PhD5*, Jun-Beom Park, DDS, MSD, PhD6
J Clin Endocrinol Metab
doi: 10.1210/jc.2016-2061

Note: Content is Not intended as medical advice. Please consult your health care provider regarding your specific medical condition and questions.

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Last Updated on September 9, 2016 by Marie Benz MD FAAD