Codeine-Containing Cough Syrups Abuse Associated With Abnormal Brain White Matter

MedicalResearch.com Interview with:
Ying-wei Qiu, MD
Department of Medical imaging
Guangdong No. 2 Provincial People’s Hospital
Guangzhou, China;

Medical Research: What are the main findings of this study?

Dr. Ying-wei Qiu: The main findings include:

  1. White matter (WM) integrity is abnormal in the IFO of bilateral temporal-occipital regions and right frontal region, and in the right corona radiata white matter in chronic Codeine-Containing Cough Syrups users.
  2. The abnormal white matter integrity related to the higher impulsivity in codeine-containing cough syrups users.
  3. The abnormal white matter integrity related to duration of Codeine-Containing Cough Syrups abuse in codeine-containing cough syrups users.


Medical Research: What should clinicians and patients take away from this report?

Dr. Ying-wei Qiu: Clinicians and patients should take away:

  1. Chronic Codeine-Containing Cough Syrups abuse may cause brain white matter integrity impairment progressively. Hence, early intervention may be particularly important for the treatment of Codeine-Containing Cough Syrups addiction.
  2. White matter integrity may serve as a predictor of abstinence or a potential new treatment target for Codeine-Containing Cough Syrups users.

Medical Research: What suggestions for future research do you have a result of this study?

Dr. Ying-wei Qiu:

  1. A long-term longitudinal follow up is needed in future study to assert the causation of Codeine-Containing Cough Syrups dependent and abnormalities of white matter integrity.
  2. Whether the abnormalities of white matter integrity is reversible after treatment is a interesting topic in future study.

Citation:

Abnormal White Matter Integrity in Chronic Users of Codeine-Containing Cough Syrups: A Tract-Based Spatial Statistics Study

Y.- w. Qiu, H.- h. Su, X.- f. Lv, G.- h. Jiang. Abnormal White Matter Integrity in Chronic Users of Codeine-Containing Cough Syrups: A Tract-Based Spatial Statistics Study. American Journal of Neuroradiology, 2014; DOI: 10.3174/ajnr.A4070