Newly Identified Molecule Turns Fat Storage Gene Off

MedicalResearch.com Interview with:

Prof. Jamal Tazi Institut de Génétique Moléculaire de Montpellier University of Montpellier Montpellier, Cedex, France

Prof. Jamal Tazi

Prof. Jamal Tazi
Institut de Génétique Moléculaire de Montpellier
University of Montpellier
Montpellier, Cedex, France

MedicalResearch.com: What is the background for this study? What are the main findings?

Response: Intense drug discovery efforts in the metabolic field highlight the need for novel strategies for the treatment of obesity. In this study we have used a novel approach to uncover novel drugs to treat obesity. Our approach is based on the finding that in humans the energy expenditure balance can be controlled by a single gene LMNA gene that can produce two different proteins with opposing effect on energy expenditure. We identified a molecule ABX300 that targets the expression of LMNA gene and favors energy expenditure leading to fat loss.

MedicalResearch.com: What should readers take away from your report?

Response: We can use a drug ABX300 to reduce the fat in the body and also to prevent fat accumulation when eating fat diet.

MedicalResearch.com: What recommendations do you have for future research as a result of this study?

Response: To perform clinical studies studies in humans to develop similar molecules that can treat obesity.

MedicalResearch.com: Is there anything else you would like to add?

Response: Our study was performed in obese mice, and it will be critical to perform regulatory preclinical and clinical studies to treat obese patients with ABX300 or similar molecules

MedicalResearch.com: Thank you for your contribution to the MedicalResearch.com community.

Citation:

Int J Obes (Lond). 2016 Dec 5. doi: 10.1038/ijo.2016.220. [Epub ahead of print]
Pharmacological modulation of LMNA SRSF1-dependent splicing abrogates diet-induced obesity in mice.
Santo J1, Lopez-Herrera C1, Apolit C1, Bareche Y2, Lapasset L1, Chavey C2, Capozi S2, Mahuteau F3, Najman R1,3, Fornarelli P1,3, Lopez-Mejía IC2, Béranger G4, Casas F5, Amri EZ4, Pau B6, Scherrer D1, Tazi J2.

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