Higher Risk of Cardiovascular Disease Linked to Long Term Antibiotic Use in Women

MedicalResearch.com Interview with:
Dr. Lu Qi MD PhD
Department of Epidemiology, School of Public Health and Tropical Medicine
Tulane University New Orleans, LA 70112
Department of Nutrition, Harvard T.H. Chan School of Public Health,
Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
Boston, MA 02115

Yoriko Heianza RD, PhD
Department of Epidemiology, School of Public Health and Tropical Medicine,
Tulane University
New Orleans, LA 

MedicalResearch.com: What is the background for this study? What are the main findings? 

Response: Growing data suggest that antibiotic exposure is associated with a long-lasting alteration in gut microbiota, and may be related to subsequent cardiovascular disease (CVD). We investigated associations of duration of antibiotic use in different phases of adulthood (young, middle and late adulthood) with the CVD incidence among women at usual risk.

This new analysis from the Nurses’ Health Study shows that women who take antibiotics for long periods, especially during more recent adulthood (such as  in middle- and late adulthood) had a higher risk of CVD in later life. 

MedicalResearch.com: What should readers take away from your report?

Response: Longer duration of antibiotic use may be linked to higher risk of CVD among women. 

MedicalResearch.com: What recommendations do you have for future research as a result of this work? 

Response: Studies in other populations including male participants would be needed to confirm whether our results are applicable to other populations.
Also, more research focusing on duration of antibiotic use with other metabolic disease outcomes as well as non-cardiovascular events would be important.

No disclosures 

Citation:

Yoriko Heianza, Yan Zheng, Wenjie Ma, Eric B Rimm, Christine M Albert, Frank B Hu, Kathryn M Rexrode, JoAnn E Manson, Lu Qi. Duration and life-stage of antibiotic use and risk of cardiovascular events in women. European Heart Journal, 2019; DOI: 10.1093/eurheartj/ehz231 

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1 thought on “Higher Risk of Cardiovascular Disease Linked to Long Term Antibiotic Use in Women

  1. That is very interesting. I was on antibiotics for over 6 months after a nosocomial MRSA infection that failed to heal despite wound VAC (X 3 phases), 3-5 times a week sharps debridement, Hgb AIC- normal results consistently. I just received RCA stents x 2 and will receive x 2 LAD stents on 5/17/19. I have participated in this study for a long time.

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