Tenovir Gel May Reduce Risk of Both HIV and Herpes Simplex

Dr. Salim Abdool Karim at CAPRISA Doris Duke Medical Research Institute South AfricaMedicalResearch.com Interview with:
Dr. Salim Abdool Karim at CAPRISA
Doris Duke Medical Research Institute
South Africa

Medical Research: What is the background for this study? What are the main findings?

Response: Globally, Herpes simplex virus type-2 (HSV-2) is among the most common sexually transmitted infections and is the leading cause of genital ulcers. Available global estimates indicate that approximately 417 million sexually active adults between the ages of 15 and 49 years had an existing prevalent HSV-2 infection in 2012. Current interventions to prevent HSV-2 infection, including condoms, circumcision, and antiviral treatment among heterosexual, HSV-2-discordant couples, have demonstrated protection levels ranging from 6% to 48%. This study showed that peri-coital tenofovir gel reduced HSV-2 acquisition in women by 51%, rising to 71% in high gel-users.

Medical Research: What should clinicians and patients take away from your report?

Response: If licensed, tenofovir gel could potentially be used as a HSV-2 prevention strategy for women unable to negotiate condom use. Tenofovir gel, when used, has also been shown to be effective in reducing HIV risk.  Given the close association between HSV-2 infection and the increased risk of HIV acquisition in women, tenofovir gel has the potential to empower women to control their risk of both HIV and HSV-2.

Medical Research: What recommendations do you have for future research as a result of this study?

Response: Research on new long-acting formulations of tenofovir is needed. Since peri-coital gel adherence can be challenging for women at high-risk, especially young women who are not aware of their risk, improved long-acting formulations of tenofovir or other anti-HSV drugs are needed to provide effective long-term protection.


Tenofovir Gel for the Prevention of Herpes Simplex Virus Type 2 Infection

Salim S. Abdool Karim, M.B., Ch.B., Ph.D., Quarraisha Abdool Karim, Ph.D., Ayesha B.M. Kharsany, Ph.D., Cheryl Baxter, Ph.D., Anneke C. Grobler, Ph.D., Lise Werner, M.Sc., Angela Kashuba, Pharm.D., Leila E. Mansoor, Ph.D., Natasha Samsunder, B.Tech., Adrian Mindel, M.D., and Tanuja N. Gengiah, Ph.D. for the CAPRISA 004 Trial Group

N Engl J Med 2015; 373:530-539
August 6, 2015 DOI: 10.1056/NEJMoa1410649

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Dr. Salim Abdool Karim at CAPRISA (2015). Tenovir Gel May Reduce Risk of Both HIV and Herpes Simplex MedicalResearch.com : https://medicalresearch.com/author-interviews/tenovir-gel-ma…herpes-simplex/16349

Last Updated on August 6, 2015 by Marie Benz MD FAAD