Serena Day, MDOhio State University.

Opioid Crisis Linked To Rapid Increase in Chronically Infected Heart Valves Interview with:

Serena Day, MDOhio State University.

Dr. Serena Day

Serena Day, MD
Ohio State University What is the background for this study? What are the main findings?

Response: The idea for this research came from my own observations of patients that I was caring for in the hospital first as an Internal Medicine Resident and now as a senior Cardiology Fellow. I did my residency here at Ohio State and noticed a marked increase in the number of patients with endocarditis that we were caring for just in my short time here as a trainee.

Over 5 years, we saw an increase of 436% in intravenous drug use related endocarditis. How this disease is treated as changed as well. It used to be that if a patient was a good surgical candidate, we would offer a replacement valve. Now, we see that these patient’s have such a high rate of recurrent intravenous drug use and reinfection of their heart valves that we now treat with antibiotics only rather than surgery. In many cases, the infection never goes away because we can’t offer definitive therapy with surgery due to their high relapse and reinfection rates of nearly 50%. What should readers take away from your report?

Response: The opioid crisis is not just about overdoses and drug dependency. Injection drug use can lead to infected heart valves which can result in complications such as heart failure, stroke, and frequently death. With such high relapse rates, comprehensive treatment targeted at drug addiction is the only way to prevent continued complications. What recommendations do you have for future research as a result of this work?

Response: Including mandatory counseling and rehabilitation into any treatment plan for these patients should be imperative. Outcomes utilizing this intervention should be evaluated so that we can finally provide comprehensive treatment to this difficult patient population.

No disclosures


Infective Endocarditis Trends Amongst Intravenous Drug Users: an Examination of Practice Patterns in a Mid-western Tertiary Care Center

Serena DayNeha PatelScott Maffett

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Last Updated on March 18, 2019 by Marie Benz MD FAAD