15 Jul “Loose” RNA Stimulates Regeneration of Skin

MedicalResearch.com Interview with:

Dr. Garza

Luis Garza, M.D., Ph.D.
Associate Professor of Dermatology
Johns Hopkins University School of Medicine.

MedicalResearch.com: What is the background for this study? What are the main findings?

Response: We wanted to find out what might stimulate regeneration in mice and humans. We find that in both species during wounding, released “loose” dsRNA induces production of retinoic acid that stimulates regeneration.

MedicalResearch.com: What should readers take away from your report? 

Response: Many of the common ways dermatologists use to increase youthfulness appearance, like lasers or dermabrasion or microneedling, likely work through loose dsRNA inducing local retinoic acid. Retinoic acid itself is already used to treat photoaged skin (Renova).

MedicalResearch.com: What recommendations do you have for future research as a result of this work?

Response: We are currently looking at therapeutics that might stimulate this effect that do not require invasive procedures like laser.

Any disclosures? Hopkins holds a patent on this technology

Citation:

Dongwon Kim, Ruosi Chen, Mary Sheu, Noori Kim, Sooah Kim, Nasif Islam, Eric M. Wier, Gaofeng Wang, Ang Li, Angela Park, Wooyang Son, Benjamin Evans, Victoria Yu, Vicky P. Prizmic, Eugene Oh, Zixiao Wang, Jianshi Yu, Weiliang Huang, Nathan K. Archer, Zhiqi Hu, Nashay Clemetson, Amanda M. Nelson, Anna Chien, Ginette A. Okoye, Lloyd S. Miller, Gabriel Ghiaur, Sewon Kang, Jace W. Jones, Maureen A. Kane, Luis A. Garza. Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3. Nature Communications, 2019; 10 (1) DOI: 10.1038/s41467-019-10811-y 

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Last Updated on July 15, 2019 by Marie Benz MD FAAD