11 Jul Overweight, Tall Men Have Greater Risk of Aggressive Prostate Cancer

MedicalResearch.com Interview with:

Dr. Perez-Cornago

Aurora Perez-Cornago, PhD
Cancer Epidemiology Unit
Nuffield Department of Population Health
University of Oxford

MedicalResearch.com: What is the background for this study? What are the main findings?

Response: Greater height and adiposity have been suggested as possible prostate cancer risk factors, but these associations are not clear, probably
because most previous studies have not looked separately at different tumour subtypes.

For this reason, we wanted to look at these associations splitting tumours into subtypes according to tumour stage and histological grade, looking as well at death from prostate cancer.

We found a marked difference in risks looking at low and high risk tumours. Taller men and men with greater adiposity had an elevated of high-grade prostate cancer and prostate cancer death.

MedicalResearch.com: What should clinicians and patients take away from your report?

Response: Our results emphasize the importance of studying risk factors for advanced stage and high grade tumours separately when assessing risk factors for prostate cancer. These findings are in line with health advice for other non-communicable diseases and should encourage men to have a healthy weight.

MedicalResearch.com: What recommendations do you have for future research as a result of this study?

Response: We need more studies to understand possible mechanisms and to establish
whether the associations we have seen are causal.

MedicalResearch.com: Thank you for your contribution to the MedicalResearch.com community.

Citation:

Tall height and obesity are associated with an increased risk of aggressive prostate cancer: results from the EPIC cohort study 

Perez-Cornago A., Appleby P., Pischon T., Tsilidis K., Tjønneland A., Olsen A., Overvad K., Kaaks R., Kühn T., Boeing H., Steffen A., Trichopoulou A., Lagiou P., Kritikou M., Krough V., Palli D., Sacerdote C., Tumino R., Bueno-de-Mesquita HB., Agudo A., Larrañaga N., Molina-Portillo E., Barricarte A., Chirlaque M-D., Quirós JR., Stattin P., Häggström C., Wareham N., Khaw K-T., Schmidt JA., Gunter M., Freisling H., Aune D., Ward H., Riboli E., Key T., Travis RC.

https://ora.ox.ac.uk/objects/uuid:05972935-882e-45bf-b5fb-f8ff0a799a53

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Last Updated on July 17, 2017 by Marie Benz MD FAAD