03 Jul Zero-Calorie Sweeteners During Pregnancy Can Impact Offspring’s Microbiome
MedicalResearch.com Interview with:
John A. Hanover, Ph.D
Chief: Laboratory of Cell and Molecular Biology
Cell Biochemistry Section, Laboratory of Cell and Molecular Biology
Director: Genomics Core, Cores and Support Services
The National Institute of Diabetes and Digestive and Kidney Diseases
MedicalResearch.com: What is the background for this study?
Response: We are interested in the impact of early nutrition on metabolic reprogramming in mammals. In particular, we are interested in how the nutritional information may be transferred from mother to offspring.
To this end, we have exposed mice to high sugar and high fat diets. One arm of these studies was to examine the effects of exposure of pregnant mice to artificial sweeteners and the subsequent changes in her offspring. This has not been examined and was important control for the studies outlined above.