18 Feb Photodynamic Therapy May Enhance Antibiotic Susceptibility
MedicalResearch.com Interview with:
Jennifer Machado Soares
Affiliation: University of São Paulo and Texas A&M University
Institute of Physics of São Carlos, University of São Paulo, São Carlos, SP, Brazil.
MedicalResearch.com: What is the background for this study?
Response: Antibiotic treatments are becoming less effective due to the increasing prevalence of multidrug-resistant bacteria. Alternative treatments such as Antimicrobial photodynamic therapy (aPDT) have emerged and can act as an adjuvant to traditional antibiotic therapy. aPDT utilizes a photosensitizer activated by light to generate reactive oxygen species that can inactivate pathogens.
MedicalResearch.com: What are the main findings?
Response: Our studies show photooxidative stress can also modulate the bacteria cell, enhancing antibiotic susceptibility. Thus, antibiotic therapy can show better results even in multidrug resistance when combined with aPDT.
MedicalResearch.com: What should readers take away from your report?
Response: The study of combination therapies is not trivial; it involves a series of variables (light dose, concentrations, time, combination order) that can lead to an antagonistic or synergistic response. However, these metrics should not only be accounted for but also the biological effects of the bacterial culture, such as metabolic and structural changes.
MedicalResearch.com: What recommendations do you have for future research as a results of this study?
Response: APDT has demonstrated success over several years as an alternative treatment for infectious diseases. Although antibiotic therapy remains the first choice, the way to introduce the technique as a treatment option is to understand the dynamics of interaction between the methods and not limit yourself to this but to explore the other responses that can be modulated via aPDT with different light dose and photosensitizer, to improve the therapeutic response
Citation: Soares JM, Yakovlev VV, Blanco KC, Bagnato VS. Photodynamic inactivation and its effects on the heterogeneity of bacterial resistance. Sci Rep. 2024 Nov 16;14(1):28268. doi: 10.1038/s41598-024-79743-y. Erratum in: Sci Rep. 2024 Dec 3;14(1):30124. doi: 1 https://pubmed.ncbi.nlm.nih.gov/39550440/0.1038/s41598-024-81888-9. PMID: 39550440; PMCID: PMC11569256.
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Last Updated on February 18, 2025 by Marie Benz MD FAAD