Author Interviews, Endocrinology, Gender Differences, Social Issues / 18.04.2019

MedicalResearch.com Interview with: Dr. Eider Pascual-Sagastizabal, PhD Professor of Evolutionary Psychology and Education University School of Education of Bilbao (Leioa) University of the Basque Country  MedicalResearch.com: What is the background for this study? What are the main findings? Response: The search for markers of aggression during childhood is a particularly relevant area of research, since the results of intervention and prevention during this developmental stage are more promising than those obtained during later stages. The psychobiological approach to aggressive behavior is of particular importance, as it analyzes the joint, interactive influence of both psychological and biological variables. We have found that there are different interactions on a biological and psychological level that could account for aggressive behavior in children. More deeply, empathy and hormones could together account for aggressive behavior. In fact, the interactions were different for boys and for girls.  (more…)
Author Interviews, JAMA, Pediatrics, Social Issues / 28.12.2018

MedicalResearch.com Interview with: Dr. Richard E. Tremblay, PhD, Professor Department of Pediatrics and Department of Psychology University of Montreal, Montreal, Quebec, Canada School of Public Health, University College Dublin, Dublin, Ireland MedicalResearch.com: What is the background for this study?   Response: Adolescent who have frequently use physical aggression are at high risk of school failure, criminal behavior, as well as physical and mental health problems. A major limit to preventive interventions is our ability to trace the developmental trajectories of physical aggression from infancy to adolescence using a uniform source of information. (more…)
Author Interviews, Gender Differences / 29.11.2018

MedicalResearch.com Interview with: Emily J. Cross, MS School of Psychology, Science Centre The University of Auckland Auckland  MedicalResearch.com: What is the background for this study? Response: Aggression and violence in intimate relationships is very harmful, and unfortunately Aggression and violence in intimate relationships is very harmful, and unfortunately very common. So identifying what predicts relationship aggression and why is important. Men’s hostile sexism toward women is an established risk factor for relationship aggression, but we actually know little about why these attitudes promote relationship aggression. Understanding why helps to identify how these damaging processes may be reduced. (more…)
Author Interviews, Genetic Research, Mental Health Research / 14.08.2018

MedicalResearch.com Interview with: Prof. Carmen Sandi Director, Brain Mind Institute Laboratory of Behavioral Genetics Brain Mind Institute Ecole Polytechnique Federale de Lausanne Lausanne, Switzerland  MedicalResearch.com: What is the background for this study? What are the main findings? Response: We are interested in understanding how the brain regulates social behaviors and aggression, both in healthy individuals and individuals with psychiatric disorders. In our recent publication in Molecular Psychiatry, we investigated the impact of an alteration in a gene, St8sia2, that plays important roles during early brain development. Alterations in this gene have been linked with schizophrenia, autism and bipolar disorder, and individuals with these disorders frequently present high aggressiveness. In addition, expression of this gene in the brain can be altered by stressful insults during very early life and development. Our study shows that genetic and environmental conditions linked to a reduction in the expression of this neuroplasticity gene during early life can lead to impaired fear learning and associated pathological aggression. We could further reveal that deficits in St8sia2 expression lead to a dysfunction in a receptor in the amygdala (a brain region critically involved in emotionality and fear learning), the GluN2B subunit of NMDA Receptors. This allowed us to target this receptor with D-cycloserine, a drug that facilitates NMDA receptor function. This treatment, when given acutely, ameliorated the capacity to learn from adversity and reduced individuals’ aggressiveness.  (more…)