MedicalResearch.com interview with:
Sylvain Lamure, MD, Hematologist, Principal Investigator
Pascale Fabbro-Peray, MD, PhD , Epidemiologist, Senior Investigator
University of Montpellier, France
MedicalResearch.com: What is the background for this study?
Response: Occupational exposure to pesticides is a well-documented associated factor for non-Hodgkin lymphoma. The main biological mechanisms of both pesticides and chemotherapy are genotoxicity and reactive oxygen species generation. Cellular adaptation among patients exposed to low doses of genotoxic and oxidative compounds might hinder chemotherapy efficiency in lymphoma patients. T
hus, we have investigated the association of occupational exposure with response to immunochemotherapy and survival in the subgroup of diffuse large B cell lymphoma, whose treatment is standardized.