Author Interviews, Heart Disease, Stem Cells / 13.11.2023

MedicalResearch.com Interview with: Prof. Dr. Wolfram-Hubertus Zimmermann Director, Institute of Pharmacology and Toxicology University Medical Center Göttingen Georg-August University Göttingen, Germany   MedicalResearch.com: What is the background for this study? Response: Involvement in research and development in the field of tissue engineered heart repair since 25+ years. Bench-to-bed translation of our research. MedicalResearch.com: How are the stem cell obtained? Response: We make use of induced pluripotent stem cells as starting material to obtain heart muscle cells for the engineering of Engineered Human Myocardium (EHM) and its use as Biological Ventricular Assist Tissue (BioVAT). (more…)
Author Interviews, Brigham & Women's - Harvard, Endocrinology, Fertility, Lancet, OBGYNE / 25.07.2023

MedicalResearch.com Interview with: Raymond M. Anchan, MD, Ph.D. Director, Stem Cell Biology and Regenerative Medicine Research Laboratory Assistant Professor, Harvard Medical School Obstetrics/Gynecology Center for Infertility and Reproductive Surgery Brigham and Women's Hospital MedicalResearch.com: What is the background for this study? Response: As a reproductive endocrinologist, I have the privilege of caring for patients who unfortunately experience premature ovarian insufficiency- Some of these patients are as young as 17 yo. Additionally, a significant number of patients over the years have been reproductive age women who have breast cancer and ovarian failure from chemotherapy.  These patients have been my inspiration to try to find a treatment for them.  Since my earlier days as a neurobiologist and stem cell scientist, it was a natural course for me to seek cell-based therapies that are patient specific using autologous iPSCs. (more…)
Author Interviews, Nature, Stem Cells / 05.09.2022

MedicalResearch.com Interview with: Gianluca Amadei PhD Post-Doctoral Fellow University of Cambridge, UK MedicalResearch.com: What is the background for this study? What are the main findings? Response: The background of this study is that we tried to build a structure that looks and develops like a real mouse embryo using different kinds of mouse stem cells. The main findings are that the resulting structures develop the entire embryonic body axis and the extraembryonic tissues that are required to support embryonic development. Our structures develop to a stage comparable to 8.5 days of embryonic development of the natural mouse embryos and have a brain and neural tube, a beating heart-like structure, gut and primordial germ cells. (more…)