Author Interviews, Baylor College of Medicine Houston, Brain Injury, Depression, JAMA / 26.09.2016
Depressive disorders are the most frequent neuropsychiatric complication of TBI
MedicalResearch.com Interview with:
Ricardo E. Jorge MD
Professor of Psychiatry and Behavioral Sciences
Director Houston Translational Research Center for TBI and Stress Disorders
Senior Scientist Beth K. and Stuart C. Yudofsky Division of Neuropsychiatry
Michael E DeBakey VA Medical Center
Baylor College of Medicine
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Depressive disorders affect between one-third and one-half of patients with traumatic brain injury. Once established, these disorders are difficult to treat and frequently follow a chronic and refractory course.
Depression has a deleterious effect on TBI outcomes, particularly affecting the community reintegration of TBI patients.
In this randomized clinical trial that included 94 adult patients with TBI, the hazards for developing depression for participants receiving placebo were about 4 times the hazards of participants receiving sertraline treatment.
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