Alzheimer's - Dementia, Author Interviews, Memory, Pharmacology / 12.09.2019
Enzyme Inhibitor Shows Promise in Treating Memory Deficits in Alzheimer’s
MedicalResearch.com Interview with:
James O’Donnell, PhD
Dean and professor
Pharmacy and Pharmaceutical Sciences
University at Buffalo School of Pharmacy
Ying Xu, MD, PhD
Research associate professor
University at Buffalo School of Pharmacy and Pharmaceutical Sciences
MedicalResearch.com: What is the background for this study?
Response: We have been studying cyclic nucleotide phosphodiesterase (PDE), an enzyme, for quite a while as a potential target for neuropsychiatric disease. One aspect involves the effects of PDE inhibitors on memory. This was prompted by our earlier finding that one form of the enzyme, PDE4, is in the NMDA receptor signaling pathway in neurons; this pathway has been implicated in memory. (more…)
Ying Xu, MD, PhD
Research associate professor
University at Buffalo School of Pharmacy and Pharmaceutical Sciences
MedicalResearch.com: What is the background for this study?
Response: We have been studying cyclic nucleotide phosphodiesterase (PDE), an enzyme, for quite a while as a potential target for neuropsychiatric disease. One aspect involves the effects of PDE inhibitors on memory. This was prompted by our earlier finding that one form of the enzyme, PDE4, is in the NMDA receptor signaling pathway in neurons; this pathway has been implicated in memory. (more…)