Author Interviews, COVID -19 Coronavirus, JAMA, Vaccine Studies / 03.09.2021
COVID-19: Subtle Differences in Immune Response to Pfizer vs Moderna Vaccines
MedicalResearch.com Interview with:
Jeffrey M. Wilson MD
Assistant Professor of Medicine
Allergy and Immunology
University of Virginia
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: To date there have been few head-to-head studies evaluating the immune responses to COVID-19 vaccines. Here we measured IgG antibodies to the SARS-CoV-2 spike-RBD in adults who received full vaccination with either the Pfizer/BioNTech or Moderna vaccine. Our study is distinguished from many others because we developed a quantitative test with a read-out in standardized units (expressed as micrograms/mL).
We found that antibody levels to the SARS-CoV-2 spike receptor-binding domain were lower in recipients of the Pfizer/BioNTech than Moderna vaccine. The difference in the antibody levels between vaccines was most evident in relatively older subjects.
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