Dermatology, Vitamin C / 04.08.2025

MedicalResearch.com Interview with: Dr. Akihito Ishigami Ph.D. Vice President of the Division of Biology and Medical Sciences Tokyo Metropolitan Institute for Geriatrics and Gerontology, Japan MedicalResearch.com: What is the background for this study? Response: Keratinocyte differentiation is a highly regulated process essential for the stratified structure of the epidermis and must be balanced with cell proliferation. While Vitamin C (VC) is a known cofactor for DNA demethylation enzymes, its specific role in DNA demethylation during keratinocyte differentiation was unclear. This study aimed to evaluate VC's role in the epigenetic regulation of epidermal proliferation and differentiation using a human epidermal equivalent model to understand how VC affects gene expression via DNA demethylation changes.
Author Interviews, Critical Care - Intensive Care - ICUs, NEJM, Vitamin C / 15.06.2022

MedicalResearch.com Interview with: François Lamontagne MD MSc (pharmacology) MSc (CEB) Professor of Medicine at the Université de Sherbrooke Endowed research chair on patient-centred research Dr. Neill Adhikari MDCM, M.Sc. Sunnybrook Research Institute and University of Toronto Toronto, Canada MedicalResearch.com:  What is the background for this study?  Response: The use of intravenous vitamin C for sepsis has been a hot topic for a few years. It was biologically plausible that vitamin C could reduce organ injury and death by scavenging reactive oxygen species and modulating the immune response to sepsis. It also seemed like an intervention that would be reasonably easy to administer globally should it prove beneficial. On the other hand, no intervention is benign and every aspect of health care should be rigorously studied. Regarding vitamin C, there were strongly held opinions in both camps and this motivated us to design and conduct the LOVIT trial.