Vitamin D and Calcium Supplements Did Not Lower Fracture Risk In Community-Dwelling Adults

MedicalResearch.com Interview with:
“ZMA och D-vitamin. Intages med dubbelsidig C-brus. #placebomannen” by Robin Danehav is licensed under CC BY 2.0Dr Jia-Guo Zhao

Tianjin Hospital
Department of Orthopaedic Surgery
Tianjin, China

MedicalResearch.com: What is the background for this study?

Response: The increased social and economic burdens for osteoporotic-related fractures worldwide make its prevention a major public health goal.

Calcium and vitamin D supplements have long been considered a basic intervention for the treatment and prevention of osteoporosis. Survey analysis showed that 30–50% of older people take calcium or vitamin D supplements in some developed countries. Many previously published meta-analyses, from the high-ranking medical journals, concluded that calcium and vitamin D supplements reduce the incidence of fracture in older adults. And many guidelines regarding osteoporosis recommend calcium and vitamin D supplements for older people. The final aim for these supplements is to prevent the incidence of osteoporotic-related fracture in osteoporosis management.

Continue reading

Older, Frail and Physically Inactive Adults At Risk of Multivitamin Deficiency

MedicalResearch.com Interview with:
“vitamins” by Colin Mutchler is licensed under CC BY 2.0
Priv.-Doz. Dr. Barbara Thorand 
Helmholtz Zentrum München
German Research Center for Environmental Health
Institute of Epidemiology II
Neuherberg, Germany 

MedicalResearch.com: What is the background for this study?

Response: Micronutrients, which include vitamins, minerals (e.g. calcium) and trace elements (e.g. iron), are essential nutrients that are required in minute amounts by the organism for proper growth and good health. Results from the last German National Nutrition Survey (NVS II)* uncovered a high prevalence of insufficient dietary intake of micronutrients in older adults aged 65 years and over in Germany. By means of blood analyses, our study has confirmed these critical results. This is a highly relevant issue, particularly in light of our growing aging population and the high societal relevance of successful healthy aging.

*Max Rubner-Institut: Nationale Verzehrsstudie II, Ergebnisbericht Teil 2 (2008). Die Bundesweite Befragung zur Ernährung von Jugendlichen und Erwachsenen.

Continue reading

Variable Effects of Vitamin C on Post-Operative Atrial Fibrillation

MedicalResearch.com Interview with:

Dr-Harri-Hemilae.jpg

Dr. Harri Hemilae

Harri Hemilä, MD, PhD
Department of Public Health
University of Helsinki

MedicalResearch.com: What is the background for this study?

Response: I have a long term interest in vitamin C. Previously I have shown that it alleviates exercise-induced bronchoconstriction (EIB) (http://dx.doi.org/10.1186/1710-1492-10-58 ) and shortens the duration of colds ( http://dx.doi.org/10.1371/journal.pmed.0020168 ). Now I had been following the literature and I noted that a number of randomized trials were being published about vitamin C for preventing post-operative atrial fibrillation (POAF). Therefore I reasoned that it is worthwhile to analyze that set of trials

Continue reading

Screening Tears, Not Blood, For Vitamin Deficiencies

MedicalResearch.com Interview with:

Adrienne R. Minerick, Ph.D. Associate Dean for Research & Innovation, College of Engineering Assistant to the Provost for Faculty Development Professor, Chemical Engineering Michigan Technological University Houghton, MI 49931

Dr. Adrienne Minerick

Adrienne R. Minerick, Ph.D.
Associate Dean for Research & Innovation, College of Engineering
Assistant to the Provost for Faculty Development
Professor, Chemical Engineering
Michigan Technological University
Houghton, MI 49931

MedicalResearch.com: What is the background for this study? What are the main findings?

Response: With seed funding from the Gerber Foundation, we asked two scientific questions.
1. Are vitamins present in tears and could we reliably detect them?
2. Do the vitamin levels in tears correlate with the vitamin levels in blood?

This research, conducted by recent PhD graduate Maryam Khaksari, illustrated that vitamins are present in tears. The majority of the essential vitamins are water soluble, which were present in tears in higher concentration than fat soluble vitamins. Given that tears are 98% water, this result wasn’t surprising. This study developed up protocols to reliably detect both water and fat soluble vitamins. The limits of detection and limits of quantification did vary by vitamin, so there is ample room to improve this technique.
The second question was answered by a small clinical trial with UP Health: Portage Hospital’s Pediatric Clinic. During the 4-month well-baby check-up, willing parents and their infant each donated both a blood sample and a tear sample. Vitamin concentrations were determined in the samples and correlations quantified. Fat soluble vitamin K showed the strongest concentration correlation between blood and tears. The strength of additional vitamin correlations were noted. These early-stage results demonstrate that vitamin screening from a single drop of tears (35uL or microliters) is feasible – with additional refinement.

Continue reading

Vitamin C Rich Diet, Not Supplements, May Slow Progression of Cataracts

MedicalResearch.com Interview with:

Christopher J. Hammond, MD, FRCOphth Departments of Ophthalmology & Twin Research King's College London St. Thomas' Hospital London UK

Dr. Chris Hammond

Christopher J. Hammond, MD, FRCOphth
Departments of Ophthalmology & Twin Research
King’s College London
St. Thomas’ Hospital
London UK 

MedicalResearch.com: What is the background for this study? What are the main findings?

Dr. Hammond: Twin studies allow us to quantify the influence of genes vs environment on a trait and this study suggests 65% of variation of cataract progression is due to environmental factors.

Vitamin C has long been linked to cataract because the lens of the eye is bathed in fluid rich in ascorbate, a derivative of vitamin C. We showed that, even in a relatively well-nourished UK population, those in the highest third of vitamin C dietary intake (equating to something like 3 times the RDA of 60mg) had a third less progression of lens opacities.

Continue reading

Low Dose Vitamin C May Improve Iron Deficiency in Dialysis Patients

MedicalResearch.com Interview with:
Dr. Tanjim Sultana MD
Department of Nephrology
Lenox Hill Hospital New York

Medical Research: What is the background for this study? What are the main findings?

Response: Almost all dialysis patients are anemic. One quarter of patients requiring High dose Epogen have functional iron deficiency, which means they have adequate iron store but unable to utilize it. Vitamin C has been shown to mobilize iron from their storage and making it available to use in red blood cell production. Prior studies showed intravenous high dose vitamin C could increase hemoglobin levels and decrease epogen requirement. In our study we used daily low dose oral vitamin C in functional iron deficient patients to achieve the same goals. Patients taking daily low dose vitamin C for 3 months had significant decrease in their epogen dose compared to the control group.

Continue reading

Effect of Vitamin C on Exercise-induced Bronchoconstriction

Harri Hemilä, MD PhD Department of Public Health University of Helsinki, POB 41 Helsinki, FinlandMedicalResearch.com Interview with:
Harri Hemilä, MD PhD
Department of Public Health
University of Helsinki, POB 41
Helsinki, Finland

 

Medical Research: What is the background for this study? What are the main findings?

Dr. Hemilä: I have a two decade interest in the effects of vitamin C on respiratory symptoms and I am the first author of the Cochrane review on vitamin C and the common cold. Since there is very strong evidence that vitamin C is better than placebo, in the Cochrane review we encourage common cold patients to try if vitamin C helps them.

In 2009, I was taking a look at the Cochrane review on vitamin C and asthma. I was puzzled with the text and figures since my own impression of the RCTs on vitamin C and asthma was quite different from what the review presented. Therefore I took a close look at the Cochrane review and I saw that it was sloppy. There were severe errors in data extraction and data analysis. For example, they used un-paired t-test when they should have used the paired t-test. That types of questions are very basic in biostatistics. I wrote a feedback to that Cochrane review and the review was withdrawn in 2013. It had been misleading readers for a decade. As a positive result of that incident, I became interested in the effects of vitamin C on asthma and I conducted a meta-analysis of three RCTs on vitamin C and exercise-induced bronchoconstriction (EIB). I calculated that vitamin C caused a 48% reduction (95% CI 33% to 64%) in the postexercise FEV1 decline. That study was published in BMJ Open in 2013 (http://www.ncbi.nlm.nih.gov/pubmed/23794586).

Continue reading

Vitamins C and E Found To Have No Effect On Risk of Cancer

MedicalResearch Interview with:
Dr. Lu Wang MD PhD
Associate Epidemiologist, Brigham and Women’s Hospital
Assistant Professor of Medicine, Harvard Medical School
Brigham and Women’s Hospital
Department of Medicine Preventive Medicine
Boston, MA 02115

Medical Research: What are the main findings of the study?

Dr. Wang: We found that vitamin E supplement 400 IU every other day and vitamin C supplement 500 mg daily had no effect on total cancers, the incidence of prostate cancer and other site-specific cancers during periods of intervention, post-trial observation, or overall.
Continue reading

Coronary Angiography: Vitamin C and Protection Against Contrast-Induced Kidney Disease

MedicalResearch.com Interview with:
Umar Sadat, MD, PhD
Addenbrooke’s Hospital
Cambridge, United Kingdom

MedicalResearch.com: What are the main findings of the study?

Dr. Sadat: Vitamin C offers significant nephroprotection against contrast induced-acute kidney injury (CI-AKI) in patients undergoing coronary angiography.
Patients receiving Vitamin C were observed to have 33% less risk of CI-AKI compared to those receiving placebo or other treatment.
Continue reading

Vitamin C, Gene Activation and In-Vitro Fertilzation

Interview with: Miguel Ramalho-Santos, Ph.D. University of California - San Francisco stem-cell scientist,MedicalResearch.com  Interview with: Miguel Ramalho-Santos, Ph.D.
University of California – San Francisco stem-cell scientist,

VitaminC induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells

MedicalResearch.com: What are the main findings of the study?

Answer: We found that Vitamin C has a profound effect in the regulation of gene activity in cultured mouse embryonic stem cells. Vitamin C specifically enhances the action of enzymes called Tet’s, which remove certain chemical modifications to DNA (methylation). In this way, Vitamin C makes cultured mouse embryonic stem cells behave more like the early cells in the embryo that they represent.
Continue reading

Vitamin C may alleviate exercise-induced Bronchoconstriction

Interview with: Dr. Harri Hemila  Department of Public Health, University of Helsinki, Helsinki, FinlandMedicalResearch.com: Interview with: Dr. Harri Hemila

Department of Public Health,
University of Helsinki, Helsinki, Finland

MedicalResearch.com: What are the main findings of the study?

HH: Vitamin C administration may halve the exercise-induced FEV1 decline in people who suffer from exercise-induced bronchoconstriction.
Continue reading