Screening Tears, Not Blood, For Vitamin Deficiencies

MedicalResearch.com Interview with:

Adrienne R. Minerick, Ph.D. Associate Dean for Research & Innovation, College of Engineering Assistant to the Provost for Faculty Development Professor, Chemical Engineering Michigan Technological University Houghton, MI 49931

Dr. Adrienne Minerick

Adrienne R. Minerick, Ph.D.
Associate Dean for Research & Innovation, College of Engineering
Assistant to the Provost for Faculty Development
Professor, Chemical Engineering
Michigan Technological University
Houghton, MI 49931

MedicalResearch.com: What is the background for this study? What are the main findings?

Response: With seed funding from the Gerber Foundation, we asked two scientific questions.
1. Are vitamins present in tears and could we reliably detect them?
2. Do the vitamin levels in tears correlate with the vitamin levels in blood?

This research, conducted by recent PhD graduate Maryam Khaksari, illustrated that vitamins are present in tears. The majority of the essential vitamins are water soluble, which were present in tears in higher concentration than fat soluble vitamins. Given that tears are 98% water, this result wasn’t surprising. This study developed up protocols to reliably detect both water and fat soluble vitamins. The limits of detection and limits of quantification did vary by vitamin, so there is ample room to improve this technique.
The second question was answered by a small clinical trial with UP Health: Portage Hospital’s Pediatric Clinic. During the 4-month well-baby check-up, willing parents and their infant each donated both a blood sample and a tear sample. Vitamin concentrations were determined in the samples and correlations quantified. Fat soluble vitamin K showed the strongest concentration correlation between blood and tears. The strength of additional vitamin correlations were noted. These early-stage results demonstrate that vitamin screening from a single drop of tears (35uL or microliters) is feasible – with additional refinement.

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Vitamin D Not A Panacea For Most Medical Conditions

MedicalResearch.com Interview with:

Michael Allan, MD CCFP Professor of Family Medicine and Director of Evidence Based Medicine Faculty of Medicine & Dentistry University of Alberta

Dr. Mike Allan

Michael Allan, MD CCFP
Professor of Family Medicine and
Director of Evidence Based Medicine
Faculty of Medicine & Dentistry
University of Alberta

MedicalResearch.com: What is the background for this study?

Dr. Allan: A large volume of observational (lower-level) research links lower Vitamin D levels with a long list of health concerns. Other non-clinical studies show the biochemical and physiological actions of Vitamin D could impact many health states. These factors have led many clinicians and scientists to advocate strongly for Vitamin D supplementation. However, this type of research can draw false connections. Therefore, we must examine high-quality randomized studies to determine if Vitamin D supplement can help people live longer, have improved health or avoid negative health outcomes.

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Parathyroidectomy Superior To Medications For Hypercalcemia in Transplant Patients

MedicalResearch.com Interview with:
Josep M Cruzado, MD
Head, Nephrology Department
Hospital Universitari de Bellvitge 

Medical Research: What is the background for this study? What are the main findings?

Dr. Cruzado: Tertiary hyperparathyroidism is frequent after renal transplantation. Inappropriately high parathyroid hormone levels are associated with hypercalcemia, hyperphosphatemia, both allograft and vascular calcification and bone mineral density loss. Cinacalcet is highly effective to control hypercalcemia in this setting although there were no studies comparing cinacalcet with subtotal parathyroidectomy.

Main findings are that subtotal parathyroidectomy is superior to cinacalcet in normalizing hypercalcemia amb iPTH, increased bone mineral density at femoral neck and is more cost effective (the cost of subtotal parathyroidectomy is equal to 14 months of cinacalcet and this drug should be maintained overtime).

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Many Parents Who Refuse Infant Vitamin K Refuse All Vaccinations For Their Children

dr_shannon_macdonaldMedicalResearch.com interview with:
Dr. Shannon MacDonald PhD
Department of Pediatrics, University of Calgary, Calgary and
Faculty of Nursing, University of Alberta, Edmonton, Alberta, Canada


Medical Research: What are the main findings of the study?

Dr. MacDonald: We found that vitamin K was refused by only a very small number of parents in our study population (0.3%) but that the number appears to be increasing (almost doubling in the past 7 years). The parents that refused vitamin K for their child were more likely to be those that delivered at home and/or with a midwife. We also found that parents who refused vitamin K for their child were also much more likely to go on to refuse all vaccinations by 15 months of age.

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Dietary Vitamin K Linked to Lower Heart Disease, Cancer Mortality

MedicalResearch.com Interview with
Mònica Bulló PhD
Human Nutrition Unit Department of Biochemistry & Biotechnology
IISPV  School of Medicine
Rovira i Virgili University
Sant Llorenç, Spain

MedicalResearch.com: What are the main findings of the study?

Dr Bulló: There is some evidence that different dietary forms of vitamin K could exert varying effects on health, however no study to date has simultaneously evaluated the potential effects of the main vitamin K forms on cancer and cardiovascular mortality. We conducted a prospective, epidemiologic study involving 7,216 elderly subjects at high cardiovascular risk who were followed for about 5 years.The results of the present study show, for the first time that an increase in dietary intake of both forms of vitamin K is related to a lower risk of cardiovascular mortality, cancer mortality or all-cause mortality.

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Diabetes: Marker for Poor Vitamin K Status Reflects Increased Cardiovascular Risk

MedicalResearch.com Interview with: Gerdien Dalmeijer

Postdoc | Julius Centrum | Universitair Medisch Centrum Utrecht
Kamernummer STR. 6.119 | Huispostnummer STR. 6.131 |
Postbus 85500| 3508GA UTRECHT

MedicalResearch.com: What are the main findings of the study?

Answer: The main findings of our prospective study among type 2 diabetes patients show that high circulating desphospho-uncarboxylated matrix Gla protein (dp-ucMGP) concentrations, reflecting a poor vitamin K status, are associated with increased cardiovascular disease risk, especially with peripheral arterial disease and heart failure. These results suggest that a poor vitamin K status is associated with increased cardiovascular disease risk.
MedicalResearch.com: Were any of the findings unexpected?

Answer: To our knowledge, this is the first study investigating the association of circulating MGP species with the risk of cardiovascular events; thus far only the association between dp-ucMGP and calcification has been investigated. Several studies but not all have shown that high dp-ucMGP concentrations are associated with increased calcification. We now extend these findings by showing the high circulating dp-ucMGP concentration is also associated with increased CVD risk, especially with peripheral arterial disease and heart failure.

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