16 Nov Vaccine Responses Can Be Improved By Manipulating Immune System
MedicalResearch.com Interview with:
Dr. Bhardwaj
Nina Bhardwaj MD, PhD
Professor of Medicine (Hematology and Medical Oncology) and Urology
Tisch Cancer Institute
Icahn School of Medicine at Mount Sinai
New York, NY
MedicalResearch.com: What is the background for this study? What types of cancer may be amenable to this vaccine?
Response: The goal was to determine if vaccine responses could be improved by increasing special white cell numbers, namely dendritic cells, which are key for jumpstarting an immune response.
MedicalResearch.com: What are the main findings?
Response: We found that the agent flt3-L mobilized these dendritic cells which help to improve the vaccine’s ability to prime the immune system.
MedicalResearch.com: What should readers take away from your report?
Response: That vaccines can be improved by manipulating the immune system – such that they can access key constituents more readily – and which results in a better immune response. By adding these agents, it may be possible to improve many vaccine formulations in the future.
MedicalResearch.com: What recommendations do you have for future research as a result of this work?
Response: It would be interesting to test the combination of this type of vaccine with approved immunooncology agents in patients with advanced cancers to see if they add any benefit.
Disclosures: I am on the advisory board of a number of companies, am a member of the CITN which funded this study and also use in other trials products made by Oncovir and Celldex.
Citation:
Bhardwaj, N., Friedlander, P.A., Pavlick, A.C. et al. Flt3 ligand augments immune responses to anti-DEC-205-NY-ESO-1 vaccine through expansion of dendritic cell subsets. Nat Cancer (2020). https://doi.org/10.1038/s43018-020-00143-y
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Last Updated on November 19, 2020 by Marie Benz MD FAAD