ASCO25: Roswell Park Researchers Find Risk of Second Primary Malignancies Higher After HPV-Associated Cancers

Pragati Advani MD, MPH, DrPH Assistant Professor of Oncology, Department of Thoracic Surgery And on faculty with the Department of Cancer Prevention and Population Sciences Roswell Park Comprehensive Cancer Center Buffalo, NY

13 Jun ASCO25: Roswell Park Researchers Find Risk of Second Primary Malignancies Higher After HPV-Associated Cancers

Posted at 15:57h in Author Interviews, Cancer Research, HPV by Marie Benz MD FAAD

MedicalResearch.com Interview with:

Dr. Advani

Pragati Advani MD, MPH, DrPH
Assistant Professor of Oncology, Department of Thoracic Surgery
And on faculty with the Department of Cancer Prevention and Population Sciences
Roswell Park Comprehensive Cancer Center
Buffalo, NY

MedicalResearch.com: What is the background for this study?

Response: In oncology, a study of second primary malignancy (SPM) is an emerging field that is predominantly driven by our success in identifying and treating the first primary cancers (FPCs). HPV is responsible for nearly a third of all infectious agent-related FPCs (including cancer of the oropharynx, anus, vulva, vagina, cervix and penis).

Advances in diagnostic and treatment methods have resulted in improved survivorship among these patients. However, they remain at risk for developing a SPM. No studies thus far had examined the risk of SPMs after HPV-associated FPCs, stratified by cancer site and gender.

MedicalResearch.com: What are the main findings?

Response: We found that – Risk of a SPM is significantly higher after all index HPV-associated FPCs, compared to the general population. SPM risk is significantly higher for second solid cancers (versus second hematological malignancies); and among solid cancers, risk is significantly higher and more pronounced in females for HPV-associated SPM (versus non-HPV SPM).

MedicalResearch.com: Were the first and subsequent tumors of the same type, ie head/neck, cervical etc?

Response: Yes, we observed remarkable similarity in HPV-associated SPM risk by HPV-associated FPC site suggesting a potential role of shared HPV-associated etiology between the two malignancies.

MedicalResearch.com: What should readers take away from your report?

Response: Because FPCs and Second primary malignancies often share risk factors, understanding the role of HPV infection in the shared etiology of HPV-associated FPCs and HPV-associated SPMs is critical in advancing surveillance guidelines for these cancer survivors.

MedicalResearch.com: What recommendations do you have for future research as a results of this study?

Response: Second Primary Malignancies have emerged as an important challenge for cancer survivors; therefore, further research to understand drivers of the observed patterns is warranted.

Citation: Meeting Abstract: 2025 ASCO Annual Meeting

Pragati Gole Advani et al.
Risk patterns for second primary malignancies among human papillomavirus (HPV)–associated first primary cancer survivors in the United States.. JCO 43, 10516-10516(2025).

DOI:10.1200/JCO.2025.43.16_suppl.10516

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Last Updated on June 13, 2025 by Marie Benz MD FAAD