10-Year Mortality Risk Raised With Atopic Dermatitis, But Lower Than Psoriasis

MedicalResearch.com Interview with:

Alexander Egeberg, MD PhD National Allergy Research Centre, Departments of Dermato-Allergology and Cardiology Herlev and Gentofte University Hospital, University of Copenhagen Hellerup, Denmark

Dr. Alexander Egeberg

Alexander Egeberg, MD PhD
Gentofte Hospital
Department of Dermatology and Allergy
Hellerup Denmark

MedicalResearch.com: What is the background for this study? What are the main findings?

Response: In recent years, numerous studies have examined the impact of psoriasis and associated comorbidities, and found a reduced lifespan in particular among patients with severe disease. However, little is known about the impact and burden of adults with atopic dermatitis. We looked at the 10-year survival among patients hospitalized for atopic dermatitis, and compared these with patients hospitalized for psoriasis, as well as with subjects from the general population.

Our main finding was that, although the mortality risk was higher for atopic dermatitis compared with general population control subjects, the risk was significantly lower compared with psoriasis patients.

MedicalResearch.com: What should readers take away from your report?

Response: While psoriasis is increasingly believed to be a disease with systemic implications, evidence suggest that the disease burden in atopic dermatitis is primarily mediated by comorbidity and modifiable life-style factors, e.g. smoking.

MedicalResearch.com: What recommendations do you have for future research as a result of this study?

Response: Recently it has been debated whether atopic dermatitis, like it has been suggested for psoriasis, is an independent risk factor for cardiovascular disease and risk of death. Emerging evidence suggests that modifiable life style factors, smoking, obesity etc. may be the culprits, rather than atopic dermatitis itself.

Future research should focus on whether modification of such risk factors, e.g. through smoking cessation, significantly alters the prognosis and disease course in atopic dermatitis.

MedicalResearch.com: Thank you for your contribution to the MedicalResearch.com community.


Ten-year mortality is increased after hospitalization for atopic dermatitis compared with the general population, but reduced compared with psoriasis

Egeberg, Alexander et al.
Journal of the American Academy of Dermatology , Volume 0 , Issue 0 ,
Journal of the American Academy of Dermatology, 10/13/2016
DOI: http://dx.doi.org/10.1016/j.jaad.2016.06.021

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Last Updated on October 13, 2016 by Marie Benz MD FAAD