25 May Metabolic Syndrome May Increase Risk of Aggressive Prostate Cancer
MedicalResearch: What are the main findings of the study?
Answer: In a study where biopsies were conducted independent from PSA, more metabolic syndrome components were found to be associated with more high-grade prostate cancers.
MedicalResearch: Were any of the findings unexpected?
Answer: While none of the findings were unexpected, we did observe a protective effect where having one component of the metabolic syndrome was associated with a decreased risk of overall and low-grade prostate cancer. Since we have found similar associations with obesity, we believe that this component may be driving the association.
MedicalResearch: What should clinicians and patients take away from your report?
Answer: Metabolic abnormalities may increase risk of aggressive prostate cancer, making good diet and lifestyle choices even more important.
MedicalResearch: What recommendations do you have for future research as a result of this study?
Answer: If these results can be confirmed, then further studies on preventing and treating metabolic abnormalities to lower risk of aggressive prostate cancer are warranted. It is also not yet clear whether treating one or more metabolic conditions can reverse the potential effects on aggressive prostate cancer risk.
Abstract presented at the 2014 American Urological Association Meeting
Metabolic syndrome components and prostate cancer risk: Results from the REDUCE study