Brian LaMoreaux, M.D., M.S. Medical Director, Medical Affairs Horizon Therapeutics

Gout Raises Risk of Amputation, Especially if Combined with Diabetes Interview with:
Brian LaMoreaux, M.D., M.S.
Medical Director, Medical Affairs
Horizon Therapeutics

Brian LaMoreaux, M.D., M.S. Medical Director, Medical Affairs Horizon Therapeutics

Dr. LaMoreaux What is the background for this study?

Response: People with diabetes are known to have an increased risk of undergoing amputation procedures, however it was not known if patients with gout have an elevated independent risk for digit or limb amputations, or whether gout potentiates amputation rates in patients with diabetes. This analysis assessed and compared the rate of amputation procedures conducted in patients with gout, diabetes, both gout and diabetes, and neither gout nor diabetes via examining records from a large US claims database. What are the main findings?

Response: Patients with gout but not diabetes suffered an approximately 3-fold increase in amputations compared to patients without either disease. Additionally, patients with both gout and diabetes had the highest risk of amputations compared to patients with only diabetes (no gout). What should readers take away from your report?

Response: The data emphasizes the urgency we already feel, as clinicians, to find an appropriate treatment option for people with gout to address uric acid buildup and reach target sUA levels. What recommendations do you have for future research as a result of this work?

Response: Because amputations are an unfavorable outcome associated with procedural complication risk and long-term sequelae, this apparent increased risk of amputation in patients with gout warrants further exploration. Additional research between these two patient populations is needed to better understand the best therapeutic approach for patients with both uncontrolled gout and diabetes to best avoid amputation procedures. 

Disclosures: I am a medical director at Horizon and a volunteer clinical rheumatologist with CommunityHealth. 



  1. Lamoreaux1, M. Francis-Sedlak1, R. Holt1

1Horizon Therapeutics, Lake Forest, United States of America


Last Modified: [last-modified]

The information on is provided for educational purposes only, and is in no way intended to diagnose, cure, or treat any medical or other condition. Always seek the advice of your physician or other qualified health and ask your doctor any questions you may have regarding a medical condition. In addition to all other limitations and disclaimers in this agreement, service provider and its third party providers disclaim any liability or loss in connection with the content provided on this website.


Last Updated on June 14, 2020 by Marie Benz MD FAAD