Liraglutide (SAXENDA) May Lead To Weight Loss By Slowing Stomach Emptying

MedicalResearch.com Interview with:

Prof Michael Camilleri, MD Gastroenterologist, Professor of Medicine, Pharmacology and Physiology at Mayo Clinic Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER) Mayo Clinic, Rochester, MN

Prof. Camilleri

Prof Michael Camilleri, MD
Gastroenterologist, Professor of Medicine, Pharmacology and Physiology at Mayo Clinic
Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER)
Mayo Clinic, Rochester, MN

MedicalResearch.com: What is the background for this study? What are the main findings?

Response: Liraglutide is approved for treatment of obesity; the precise mechanisms for the beneficial weight loss are unclear. We are interested to learn whether it is possible to identify people who are more likely to benefit from this treatment.

MedicalResearch.com: What should readers take away from your report?

1: Liraglutide appears to be very effective in inducing weight loss over three months of treatment.

2: Liraglutide dramatically slowed stomach emptying of solids and the degree of stomach emptying delay (for solids) in study participants was significantly associated with the degree of weight loss.

3. Measurement of gastric emptying of solids after approximately one month of treatment could help to identify patients who would likely respond in the long term to Liraglutide with significant weight loss.

MedicalResearch.com: What recommendations do you have for future research as a result of this study?

1) Replication of the findings from this pilot clinical trial in a larger patient cohort

2) Determine whether the baseline gastric emptying of solids is a predictor of response to treatment with liraglutide, and therefore identify even before starting treatment whether the treatment of obesity could be individualized or personalized 

Disclosures: The study was funded by NIH; some of the medication was provided free by the manufacturer, Novo Nordisk.  

MedicalResearch.com: Thank you for your contribution to the MedicalResearch.com community.

Citation:

Houssam Halawi, MD et al.Effects of liraglutide on weight, satiation, and gastric functions in obesity: a randomised, placebo-controlled pilot trial. The Lancet Gastroenterology & Hepatology, September 2017 DOI: 1016/S2468-1253(17)30285-6

Note: Content is Not intended as medical advice. Please consult your health care provider regarding your specific medical condition and questions. 

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