11 Jun Children of Older Mothers More Susceptible to Heart Disease
MedicalResearch.com Interview with:
Sandra T. Davidge, PhD, FCAHS
Executive Director, Women and Children’s Health Research Institute
Canada Research Chair in Maternal and Perinatal Cardiovascular Health
Professor, Depts. of Ob/Gyn and Physiology
University of Alberta
MedicalResearch.com: What is the background for this study?
Response: This research contributes to the growing body of literature that developmental programming of adult onset cardiovascular disease originates in the womb.
Our study is among the first to discover that maternal age may be considered a ‘prenatal stress’ in certain circumstances.
MedicalResearch.com: What are the main findings?
Response: Our findings are significant because this is one of the first studies to show that being born to an older mother may have life-long cardiovascular health implications for the offspring.
MedicalResearch.com: What do they tell us that is new?
Response: This research contributes to the growing body of literature that developmental programming of adult onset cardiovascular disease originates in the womb and that maternal age may be considered a ‘prenatal stress’ in certain circumstances.
MedicalResearch.com: What should readers take away from your report?
Response: The reader should understand that there are potential health implications of delaying childbearing that go beyond the known increased risk of pregnancy complications and may affect the health of the offspring long-term.
MedicalResearch.com: What recommendations do you have for future research as a result of this work?
Response: The next crucial step in this research is to translate our findings, which were done in an animal model, into a human population to determine if they holds true in women and their children.
MedicalResearch.com: Is there anything else you would like to add?
Response: One of the significant aspects of our study is that if these long-term health implications are confirmed in women and their children, it provides an opportunity for increased monitoring by health care providers and the potential for intervention and primary prevention of cardiovascular disease.
Christy-Lynn M. Cooke, Amin Shah, Raven D. Kirschenman, Anita L. Quon, Jude S. Morton, Alison S. Care, Sandra T. Davidge. Increased susceptibility to cardiovascular disease in offspring born from dams of advanced maternal age. The Journal of Physiology, 2018; DOI: 10.1113/JP275472
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