09 Mar Not All Patients with Coronary Artery Disease Require High Intensity Statins
MedicalResearch.com Interview with:
Myeong-Ki Hong, MD PhD
Professor of Cardiology
Yonsei University College of Medicine
Severance Cardiovascular Hospital
MedicalResearch.com: What is the background for this study?
Response: The background of this study was to compare the long-term clinical outcomes between the two distinct strategies regarding statin intensity in patients with coronary artery disease (CAD).
One is to titrate statin intensity to meet a target low-density lipoprotein cholesterol (LDL-C) level (treat-to-target strategy), the other is to maintain high-intensity statin without a target goal (high-intensity statin strategy).
MedicalResearch.com: What are the main findings?
Response: In this study, among patients with CAD, a treat-to-target LDL-C strategy of 50 – 70 mg/dL as the goal was noninferior to a high-intensity statin therapy for the 3-year composite of death, myocardial infarction, stroke, or coronary revascularization.
In the meantime, moderate-intensity and high-intensity statin were used in 43% and 54% in the treat-to-target group.
MedicalResearch.com: What should readers take away from your report?
Response: Our findings provide the readers additional evidence supporting the suitability of a treat-to-target strategy which may allow a tailored approach with consideration for individual variability in drug response to statin therapy. Not all patients require high-intensity statin therapy for the purpose of secondary prevention.
MedicalResearch.com: What recommendations do you have for future research as a results of this study?
Response: As a result of our study, future studies based on the recently proposed LDL-C target levels (below 55 mg/dL) is required. In addition, since our study focused on the secondary prevention, additional investigation regarding primary prevention is warranted
We thank and acknowledge the contribution of all patients and trial team members at each study site.
Hong S, Lee Y, Lee S, et al. Treat-to-Target or High-Intensity Statin in Patients With Coronary Artery Disease: A Randomized Clinical Trial. JAMA. Published online March 06, 2023. doi:10.1001/jama.2023.2487
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