17 May Is There a Drug to Reduce Alcohol Cravings? What You Need to Know
For many individuals struggling with alcohol use, stopping isn’t just about willpower—it’s about biology. Alcohol changes the brain’s reward system, making it harder to resist cravings even after someone decides to quit. That’s why, for some people, adding a drug to reduce alcohol cravings can be a game-changing part of recovery.
So, what medications are available, and how do they work? Here’s what science—and real-world treatment—has to say.
Understanding Alcohol Cravings
Alcohol cravings are powerful urges that often occur during withdrawal, emotional distress, or exposure to triggers. These cravings are driven by changes in brain chemistry, particularly in areas that regulate reward, motivation, and impulse control.
This is why medication-assisted treatment (MAT) can play an essential role in long-term sobriety—by helping to restore balance to the brain and reduce the risk of relapse.
FDA-Approved Medications to Reduce Alcohol Cravings
Several medications have been approved by the U.S. Food and Drug Administration (FDA) for the treatment of alcohol use disorder (AUD). These medications are most effective when combined with counseling and behavioral therapy.
1. Naltrexone
Naltrexone works by blocking opioid receptors in the brain, which reduces the pleasurable effects of alcohol and decreases cravings. It can be taken daily in pill form or as a monthly injectable (Vivitrol).
- Who it’s for: People who are still drinking and want to reduce cravings or prevent relapse.
- Evidence: According to the National Institute on Alcohol Abuse and Alcoholism (NIAAA), naltrexone has been shown to significantly reduce heavy drinking days and support long-term recovery.
2. Acamprosate (Campral)
Acamprosate helps restore the brain’s chemical balance after someone has stopped drinking. It’s typically used after detox and is most effective for individuals committed to abstinence.
- Who it’s for: People who have already quit drinking and want help staying sober.
- Benefit: Reduces post-acute withdrawal symptoms like insomnia, anxiety, and restlessness.
3. Disulfiram (Antabuse)
Disulfiram doesn’t reduce cravings directly but discourages drinking by causing unpleasant reactions when alcohol is consumed (e.g., nausea, flushing, and rapid heartbeat).
- Who it’s for: People highly motivated to stay sober and avoid relapse.
- Consideration: Works best as part of a structured program with accountability.
Are These Medications Right for Everyone?
Not everyone with alcohol use disorder needs or chooses medication, but for many, it provides critical support. A healthcare provider can assess factors like drinking patterns, health history, and motivation to determine the best treatment option.
Programs that offer personalized MAT protocols, such as those at Sequoia MD, help patients safely explore whether a drug to reduce alcohol cravings could support their sobriety goals.
What About Off-Label Options?
Some physicians may also prescribe medications off-label to support sobriety, including:
- Topiramate (Topamax) – an anti-seizure drug that reduces cravings
- Gabapentin – helpful for anxiety and insomnia during early recovery
- Baclofen – used in certain cases to reduce cravings and anxiety
These options may be used when FDA-approved drugs are ineffective or poorly tolerated.
Cravings Are Not a Sign of Failure
Experiencing cravings doesn’t mean someone isn’t trying hard enough—it means the brain is still healing. Medications can offer critical relief during this transition and make sobriety more sustainable.
If you or someone you love is looking for a drug to reduce alcohol cravings, talking to a trusted provider can be the first step toward a personalized, science-backed treatment plan.
More information:
Marin MCD, Pedro MOP, Perrotte G, Martins-da-Silva AS, Lassi DLS, Blaas IK, Castaldelli FI, Brisola Dos Santos MB, Kortas GT, Campos MW, Torales J, Ventriglio A, Périco CA, Negrão AB, Leopoldo K, de Andrade AG, Malbergier A, Castaldelli-Maia JM. Pharmacological Treatment of Alcohol Cravings. Brain Sci. 2023 Aug 15;13(8):1206.
doi: 10.3390/brainsci13081206. PMID: 37626562; PMCID: PMC10452441.
Anticraving medication for moderate to severe alcohol use disorder
- If you or someone you know is struggling or in crisis, help is available. Call or text 988 or chat at org. To learn how to get support for mental health, drug or alcohol conditions, visit FindSupport.gov. If you are ready to locate a treatment facility or provider, you can go directly to FindTreatment.govor call 800-662-HELP (4357).
- US. veterans or service members who are in crisis can call 988 and then press “1” for the Veterans Crisis Line. Or text 838255. Or chat online.
- The Suicide & Crisis Lifeline in the U.S. has a Spanish language phone line at 1-888-628-9454 (toll-free).
——–
The information on MedicalResearch.com is provided for educational purposes only and may not be up to date. It is in no way intended to diagnose, cure, or treat any medical or other condition.
Some links are sponsored. Products are not warranted or endorsed.
Always seek the advice of your physician or other qualified health and ask your doctor any questions you may have regarding a medical condition. In addition to all other limitations and disclaimers in this agreement, service provider and its third party providers disclaim any liability or loss in connection with the content provided on this website.
Last Updated on May 17, 2025 by Marie Benz MD FAAD
