19 Sep Needle-free injection of exosomes enable skin repair after UVB damage

MedicalResearch.com Interview with:

Dr. Ke Cheng

Dr. Ke Cheng, PhD
Professor, Department of Molecular Biomedical Sciences, NCSU
Professor, UNC/NCSU joint Department of Biomedical Engineering

MedicalResearch.com: What is the background for this study? What are exosomes?

Response: People are developing lots cosmetic products to keep a healthy and young appearance, like antioxidants, growth factors, peptides and more recently, stem cell products. Also, people are seeking more effective solutions for better absorption, like lotion, mask, laser and fillers. What is used for the treatment and how to deliver it are vitally important to the final effect and lasting time.

Exosomes are nano-sized small vehicles containing proteins, nucleic acids, and they are messengers for cell communication and regulation. Here we use skin cell-secreted exosomes to fight skin aging.

MedicalResearch.com: What are the main findings?

Response: We are proposing a cell-free, needle-free treatment to treat aged skin. Exosomes-treated skin was significantly refined and improved compared to commercial retinoids. What’s more, needle-free jet injector is excellent for the delivery of exosomes. The exosomes can reach deep dermis and still maintain their biological activity.

MedicalResearch.com: What should readers take away from your report?

Response: Exosomes play an important role in cell-free treatment and clinical translation. I think skin cell-derived exosomes hold great potential in rejuvenating skin cells, also, they can penetrate dermis well via jet injection methods. For lotions and mask, bioactive factors are hard to penetrate through stratum corneum, you must apply them daily to keep skin hydrated and smooth. This needle-free injection could achieve a long-lasting effect.

MedicalResearch.com: What recommendations do you have for future research as a result of this study?

Response: Cells are communicating with each other by secreting messengers. It is important to realize the messengers could be different when cells are at different state, like 2D culture, 3D spheroids, treated with drugs and cocultured with different types of cells.

MedicalResearch.com: Is there anything else you would like to add? Any disclosures?

Response: The limitation of this study is the lack of immunological study. Even though it is cell-free treatment, we would like to do more assessment in the future.

Citation:

Needle-Free Injection of Exosomes Derived from Human Dermal Fibroblast Spheroids Ameliorates Skin Photoaging. Shiqi Hu, Zhenhua Li, Jhon Cores, Ke Huang, Teng Su, Phuong-Uyen Dinh, Ke Cheng*.

ACS Nano. 26 Aug 2019. https://doi.org/10.1021/acsnano.9b04384

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Last Updated on September 19, 2019 by Marie Benz MD FAAD