21 Dec Newly Identified Molecule Turns Fat Storage Gene Off
MedicalResearch.com Interview with:
Prof. Jamal Tazi
Institut de Génétique Moléculaire de Montpellier
University of Montpellier
Montpellier, Cedex, France
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Intense drug discovery efforts in the metabolic field highlight the need for novel strategies for the treatment of obesity. In this study we have used a novel approach to uncover novel drugs to treat obesity. Our approach is based on the finding that in humans the energy expenditure balance can be controlled by a single gene LMNA gene that can produce two different proteins with opposing effect on energy expenditure. We identified a molecule ABX300 that targets the expression of LMNA gene and favors energy expenditure leading to fat loss.
MedicalResearch.com: What should readers take away from your report?
Response: We can use a drug ABX300 to reduce the fat in the body and also to prevent fat accumulation when eating fat diet.
MedicalResearch.com: What recommendations do you have for future research as a result of this study?
Response: To perform clinical studies studies in humans to develop similar molecules that can treat obesity.
MedicalResearch.com: Is there anything else you would like to add?
Response: Our study was performed in obese mice, and it will be critical to perform regulatory preclinical and clinical studies to treat obese patients with ABX300 or similar molecules
MedicalResearch.com: Thank you for your contribution to the MedicalResearch.com community.
Int J Obes (Lond). 2016 Dec 5. doi: 10.1038/ijo.2016.220. [Epub ahead of print]
Pharmacological modulation of LMNA SRSF1-dependent splicing abrogates diet-induced obesity in mice.
Santo J1, Lopez-Herrera C1, Apolit C1, Bareche Y2, Lapasset L1, Chavey C2, Capozi S2, Mahuteau F3, Najman R1,3, Fornarelli P1,3, Lopez-Mejía IC2, Béranger G4, Casas F5, Amri EZ4, Pau B6, Scherrer D1, Tazi J2.
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