X-Linked Genetic Signatures Linked To Respiratory Disorders in Males

MedicalResearch.com Interview with:

Gustavo Nino, M.D. Children’s National Health System pulmonologist Study senior author

Dr. Nino Barrera

Gustavo Nino, M.D.
Children’s National Health System pulmonologist
Study senior autho

MedicalResearch.com: What is the background for this study?

Response: The epidemiology of respiratory disorders is largely influenced by the individual’s sex resulting in overall higher risk for males than females, particularly during early life. Hormonal, anatomical and behavioral differences are postulated to play a role, but these sex-based respiratory differences are already present at birth, suggesting a strong genetic component. However, the genetic differences in the airways of males and females during early life have been remarkably understudied and are largely unknown.

MedicalResearch.com: What are the main findings?

Response: We put together a multi-disciplinary team to develop novel signal processing and machine-learning classification approaches to define DNA methylation patterns of the X-chromosome in the airways of newborns and infants. Using these genomic and computational approaches, we identified that the human airways have already sex-based epigenomic marks (including a significant number of immune-related genes) that may determine sex-based respiratory phenotypes and overall predisposition to develop respiratory disorders later in life. 

MedicalResearch.com: What should readers take away from your report?

Response: The importance of studying X-linked-based airway methylation signatures in human airways in order to understand sex-based disparities of many respiratory disorders in all ages. 

Citations:

Cesar L. Nino, Geovanny F. Perez, Natalia Isaza, Maria J. Gutierrez, Jose L. Gomez, Gustavo Nino. Characterization of Sex-Based Dna Methylation Signatures in the Airways During Early Life. Scientific Reports, 2018; 8 (1) DOI: 1038/s41598-018-23063-5

 

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