Midlife Type 2 Diabetes Mellitus Linked to Increased Risk of Ischemic Stroke Interview with:
Rongrong Yang, PhD candidate

Tianjin Medical University What is the background for this study?

Response: Worldwide, cerebrovascular disease (CBD) and type 2 diabetes mellitus (T2DM) are common disorders that have become among the top ten leading causes of death, killing approximately 8 million people in 2016. Both T2DM and CBD are complex genetic and lifestyle-related disorders. Genetic and familial environmental factors (e.g. foetal environment, maternal smoking and childhood socioeconomic status) have been shown to be involved in the development of both conditions. Accumulating evidence from previous studies suggests that T2DM is independently associated with an increased risk of CBD, especially ischemic CBD. What are the main findings? 

Response  Midlife type 2 diabetes mellitus is significantly associated with increased risk of cerebral infarction, occlusion of cerebral arteries, but not intracerebral hemorrhage or subarachnoid hemorrhage in late life. What should readers take away from your report?

Response: Our findings highlight the need for controlling midlife type 2 diabetes to help prevent cerebral infarction and occlusion of cerebral arteries in late life. What recommendations do you have for future research as a result of this work? 

Response: The role of genetic and early-life familial environmental factors in the T2DM-cerebrovascular disease association requires further large longitudinal twin studies. 


Yang R, et al “Type 2 diabetes in midlife and risk of cerebrovascular disease in late life: a prospective nested case−control study in a nationwide Swedish twin cohort” Diabetologia 2019; DOI: 10.1007/s00125-019-4892-3.

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Last Updated on June 9, 2019 by Marie Benz MD FAAD