Aging, Alzheimer's - Dementia, Author Interviews, MRI, Technology / 23.12.2019

MedicalResearch.com Interview with: Dr. Weidong Luo Principal Scientist CorTechs Labs  MedicalResearch.com: What is the background for this study? Response: We were interested in whether or not we can predict the age of the brain accurately from T1 weighted MRI and/or fluorodeoxyglucose (FDG) PET scans using the brain volumetric and the relative metabolic activity. The uptake of FDG is a clinical marker used to measure the uptake of glucose and therefore metabolism. Also, we were interested in the patterns of the predicted ages for Alzheimer's disease (AD) and minor cognitive impairment (MCI) subjects when using their brain measurements for age prediction in the normal brain age model.   (more…)
Alzheimer's - Dementia, Author Interviews / 20.09.2018

MedicalResearch.com Interview with: Dr Christina Elliott PhD Postdoctoral Researcher Department of Old Age Psychiatry King’s College London MedicalResearch.com: What is the background for this study? Response: Amyloid-beta (Aβ) and its precursor protein, APP have been long implicated in pathogenesis of Alzheimer’s Disease but how they contribute to disease is not fully understood.  This has been further compounded by numerous failed clinical trials which attempted to target Aβ therapeutically. In Alzheimer’s Disease there is an overproduction of Aβ, which can disrupt how neurons communicate at structures called synapses.  It is thought that progressive synapse loss underpins cognitive impairments commonly seen in Alzheimer Disease patients such as memory loss. Our previous work highlighted a central role of the signalling pathway Wnt signalling in Aβ mediated synapse loss through the induction of dickkopf-1 (Dkk1), a well-known modulator of Wnt signalling. The aim of this study was to further investigate the molecular mechanisms of Aβ mediated synapse loss and explore whether this is connected to the overproduction of Aβ.  By dissecting out the key signalling events involved we hoped this would allow us to identify drugs which could be putative therapeutics for Alzheimer’ Disease.   (more…)