Could Keloids Suggest Increased Risk of Breast Cancer?

MedicalResearch.com Interview with:

Lamont R. Jones, MD, MBA Vice Chair Department of Otolaryngology HNS Henry Ford Hospital Facial Plastic and Reconstructive Surgery Director Cleft and Craniofacial Clinic Otolaryngology Service Chief Henry Ford West Bloomfield Hospital

Dr. Jones

Lamont R. Jones, MD, MBA
Vice Chair
Department of Otolaryngology HNS
Henry Ford Hospital
Facial Plastic and Reconstructive Surgery
Director Cleft and Craniofacial Clinic
Otolaryngology Service Chief
Henry Ford West Bloomfield Hospital

MedicalResearch.com: What is the background for this study? What are the main findings?

Response: The objective of this study was to explore the potential link between keloid development and clinical outcomes of African American women with breast cancer.

MedicalResearch.com: Would you briefly explain what is meant by a keloid?

Response: A keloid is a benign fibrorproliferative tumor of the skin which is more common in African Americans which results from injury such as surgery, ear piercing, burns or infection.

MedicalResearch.com: What are the main findings?

Response: Keloid status of an individual may be indicative of a risk to be diagnosed with early-onset, late staged breast cancer. In addition, it was a distinguishing factor among African American women, which may point to a pathological/molecular pathway that predicates their unique cancer risk.

MedicalResearch.com: What should readers take away from your report?

Response: The research results are preliminary. However, because keloids disproportionately affect African American patients, it may serve as a model to better understand how their tissue microenvironment. Moreover, insights into keloid formation may help to identify ancestry specific biomarkers that may be used as future therapeutic targets to treat cancers in African Americans.

MedicalResearch.com: What recommendations do you have for future research as a result of this work? 

Response: Larger prospective or case control studies may provide more information and better determine the potential correlation of keloid status and breast cancer outcomes. 

Citation:

https://www.henryford.com/news/2019/01/keloids-linked-to-early-onset-and-late-stage-breast-cancer

Jan 30, 2019 @ 2:18 pm

The information on MedicalResearch.com is provided for educational purposes only, and is in no way intended to diagnose, cure, or treat any medical or other condition. Always seek the advice of your physician or other qualified health and ask your doctor any questions you may have regarding a medical condition. In addition to all other limitations and disclaimers in this agreement, service provider and its third party providers disclaim any liability or loss in connection with the content provided on this website.

 

Could Sucking the Pacifier Clean Lower Your Baby’s Allergy Antibodies?

MedicalResearch.com Interview with:

Eliane Abou-Jaoude, MD  Allergy and Immunology Fellow Henry Ford Health System Detroit, MichiganEliane Abou-Jaoude, MD 
Allergy and Immunology Fellow
Henry Ford Health System
Detroit, Michigan

MedicalResearch.com: What is the background for this study?

Response: Early life exposure to diverse types of microbes is necessary for healthy immune development and may impact the risk for developing allergic disorders.

Theoretically the transfer of parental microbes to their offspring during infancy can influence a child’s developing gut microbiome and subsequent immune response patterns.

We wished to investigate whether parental pacifier cleaning methods, reported at 6-months of age, were associated with altered serum IgE trajectory over the first 18 months of life. 

Continue reading

Routine Mammography Screening Recommendations Do Not Apply To Women With History of Breast Cancer

MedicalResearch.com Interview with:

Lisa A Newman, MD Director of the Breast Oncology Program for the multi-hospital  Henry Ford  Health System

Dr. Newman

Lisa A Newman, MD
Director of the Breast Oncology Program for the multi-hospital
Henry Ford  Health System

MedicalResearch.com: What is the background for this study? What are the main findings? 

Response: In 2009 the United States Preventive Services Task Force published a guideline recommending that American women at average risk for breast cancer defer undergoing screening mammography until they reach the age of 50 years. Prior to this publication, women were widely-encouraged to initiate annual mammography at age 40 years. Women that have a history of breast cancer are automatically considered to be at increased risk for developing a new breast cancer, and so routine screening mammography guidelines do not apply to them. These women require annual mammography regardless of age, unless they have undergone a bilateral mastectomy.

We utilized data from Michigan Blue Cross/Blue Shield to evaluate patterns of mammography utilization among women age 40-49 years, comparing rates before versus after 2009, when the USPSTF guideline was published. We analyzed women that had a prior history of breast cancer separately from those that had no history of breast cancer, and we excluded women that underwent bilateral mastectomy.

Disturbingly, we found that mammography utilization rates declined among women with a history of breast cancer as well as among those with no history of breast cancer in the post-2009 timeline.

This suggested to us that changes in screening recommendations may have had the unintended consequence of generating confusion and misunderstandings regarding the value of mammography among women that undeniably benefit from this imaging, such as those with a history of breast cancer.  Continue reading