Collagen, the most abundant protein in the human body, is crucial for maintaining the structural integrity of various tissues. In...
Author Interviews, NYU/NYMC, Orthopedics / 10.08.2020
Injections of Adenosine into Mouse Joints Reversed Osteoarthritis
MedicalResearch.com Interview with:
[caption id="attachment_55060" align="alignleft" width="149"]
Dr. Cronstein[/caption]
Bruce N. Cronstein, MD
Paul R. Esserman Professor of Medicine
NYU School of Medicine
Director, NYU-H+H Clinical and Translational Science Institute
Director, Division of Translational Medicine
NYU Langone Health
New York, NY 10016
MedicalResearch.com: What is the background for this study?
Response: Osteoarthritis is the most common type of arthritis affecting about 10% of the adult population and 25% of the population over 60. We had previously found that adenosine, a molecule generated by nearly all cell types, is critical for maintaining cartilage health by activating specific adenosine receptors on the surface of cells (A2A receptors). Moreover, giving adenosine into the joint could prevent deterioration of cartilage (progression of osteoarthritis) in a rat model of osteoarthritis. Because people do not usually go for treatment of osteoarthritis until they have developed symptoms we asked whether administration of adenosine or adenosine that had been modified to be a more potent and specific stimulus for A2A receptors, carried in fat bubbles called liposomes, could reverse osteoarthritis after it had already started.
Dr. Cronstein[/caption]
Bruce N. Cronstein, MD
Paul R. Esserman Professor of Medicine
NYU School of Medicine
Director, NYU-H+H Clinical and Translational Science Institute
Director, Division of Translational Medicine
NYU Langone Health
New York, NY 10016
MedicalResearch.com: What is the background for this study?
Response: Osteoarthritis is the most common type of arthritis affecting about 10% of the adult population and 25% of the population over 60. We had previously found that adenosine, a molecule generated by nearly all cell types, is critical for maintaining cartilage health by activating specific adenosine receptors on the surface of cells (A2A receptors). Moreover, giving adenosine into the joint could prevent deterioration of cartilage (progression of osteoarthritis) in a rat model of osteoarthritis. Because people do not usually go for treatment of osteoarthritis until they have developed symptoms we asked whether administration of adenosine or adenosine that had been modified to be a more potent and specific stimulus for A2A receptors, carried in fat bubbles called liposomes, could reverse osteoarthritis after it had already started.
MedicalResearch.com Interview with:
[caption id="attachment_32956" align="alignleft" width="130"] Dr. Michael Hausman[/caption]
Michael Hausman, MD
Chief, Hand and Upper Extremity Surgery
Mount Sinai Health System
Professor, Orthopaedics
Icahn School of Medicine at Mount Sinai
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Lateral epicondylitis has traditionally been thought of as a tendon problem, but tendon pathology has not been well documented. Our study supports our hypothesis that the problem lies within the elbow joint, rather than in the tendon outside the joint.
Dr. Michael Hausman[/caption]
Michael Hausman, MD
Chief, Hand and Upper Extremity Surgery
Mount Sinai Health System
Professor, Orthopaedics
Icahn School of Medicine at Mount Sinai
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Lateral epicondylitis has traditionally been thought of as a tendon problem, but tendon pathology has not been well documented. Our study supports our hypothesis that the problem lies within the elbow joint, rather than in the tendon outside the joint.
Author Interviews, Rheumatology / 17.04.2015
Gas Cavity Produces That Sound When You Crack Your Joints
MedicalResearch.com Interview with: Gregory N. Kawchuk Ph.D. Department of Physical Therapy Faculty of Rehabilitation Medicine University of Alberta Edmonton, Alberta, Canada Medical Research: What is...
Annals Internal Medicine, Author Interviews, Orthopedics, UCLA / 09.09.2014
Osteoporosis Medications Differ in Joint Fracture Reduction, Adverse Effects
MedicalResearch.com Interview with:
Carolyn J. Crandall, MD, MS
Professor of Medicine
David Geffen School of Medicine at University of California,
Los Angeles
Medical Research: What are the main findings of the study?
Dr. Crandall:
1. We found high-strength evidence that several medications decrease fracture risk when used by persons with bone density in the osteoporotic range and/or with pre-existing hip or vertebral fracture. While many of the medications (alendronate, risedronate, zoledronic acid, ibandronate, denosumab, teriparatide, and raloxifene) reduce vertebral fractures, a reduction in the risk of hip fracture is not demonstrated for all of the medications. In particular, hip fracture reduction is only demonstrated for alendronate, risedronate, zoledronic acid, and denosumab. Unfortunately, due to a lack of head-to-head trials, the comparative effectiveness of the medications is unclear.
2. The adverse effects of the medications vary. For example, raloxifene is associated with an increased risk of thromboembolic events, whereas denosumab and the bisphosphonate medications have been associated with increased risk of osteonecrosis of the jaw and atypical subtrochanteric femoral fractures.
