Author Interviews, Gender Differences, Sleep Disorders / 16.06.2019 Interview with: Ambra Stefani, MD Sleep Disorders Clinic Department of Neurology Innsbruck Medical University Innsbruck, Austria What is the background for this study? Response: Restless legs syndrome (RLS) is a common neurological disorder, affecting up to 10% of the general population in Europe and North America. It is a sensorimotor disorder characterized by unpleasant sensations and an urge to move, mainly involving the legs. These symptoms appear or worsen in the evening/at night and improve with movement. Background for this study was the idea that there might be gender differences in the phenotypical presentation of RLS, as the pathogenesis of this disease is multifactorial and gender specific factors also play a role. (more…)
Author Interviews, Insomnia, Kidney Disease / 04.11.2017 Interview with: Dr. Jun Ling (Lucy) Lu, MD, CCRP Senior Clinical Research Coordinator in the Department of Medicine Csaba P Kovesdy MD FASN Fred Hatch Professor of Medicine Director, Clinical Outcomes and Clinical Trials Program Division of Nephrology, University of Tennessee Health Science Center Nephrology Section Chief, Memphis VA Medical Center Memphis TN, 38163 What is the background for this study? What are the main findings? Response: Around one third of the world’s population suffers from insomnia. Previous studies showed that sleep disorders affect the hypothalamic–pituitary–adrenal axis and the sympatho-adrenal system, which may cause abnormalities in several organ systems and pathways causing metabolic or cardiovascular abnormalities. However, there is inadequate evidence of an association between chronic insomnia and adverse renal outcomes. After examining 938,473 US veterans (4.4% of them had chronic insomnia) with baseline estimated eGFR >60 ml/min/1.73m2, we found that chronic insomnia is associated with a 43% higher risk of all-cause mortality, a 2.5-fold higher incidence of eGFR ≤45ml/min/1.73m2, a 2.3-fold higher ESRD risk, and with rapid loss of kidney function. (more…)
Alzheimer's - Dementia, Author Interviews, Sleep Disorders / 29.10.2014

Christian Benedict PhD Associate Professor of Neuroscience Uppsala University Dept. of Interview with: Christian Benedict PhD Associate Professor of Neuroscience Uppsala University Dept. of Neuroscience   Medical Research: What is the background for this study? Answer: Our study involved ~1500 men who were followed from 1970 to 2010. All participants were 50 years old at the start of study. Medical Research: What are the main findings? Answer: Men with reports of sleep disturbances had a 50%-higher risk to develop Alzheimer's disease during the 40-year follow-up period, than men without reports of sleep disturbances. (more…)