04 Nov Chronic Insomnia Associated With Higher Risk of End Stage Kidney Disease and Mortality
MedicalResearch.com Interview with:
Dr. Jun Ling (Lucy) Lu, MD, CCRP
Senior Clinical Research Coordinator in the Department of Medicine
Csaba P Kovesdy MD FASN
Fred Hatch Professor of Medicine
Director, Clinical Outcomes and Clinical Trials Program
Division of Nephrology, University of Tennessee Health Science Center
Nephrology Section Chief, Memphis VA Medical Center
Memphis TN, 38163
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Around one third of the world’s population suffers from insomnia. Previous studies showed that sleep disorders affect the hypothalamic–pituitary–adrenal axis and the sympatho-adrenal system, which may cause abnormalities in several organ systems and pathways causing metabolic or cardiovascular abnormalities. However, there is inadequate evidence of an association between chronic insomnia and adverse renal outcomes.
After examining 938,473 US veterans (4.4% of them had chronic insomnia) with baseline estimated eGFR >60 ml/min/1.73m2, we found that chronic insomnia is associated with a 43% higher risk of all-cause mortality, a 2.5-fold higher incidence of eGFR ≤45ml/min/1.73m2, a 2.3-fold higher ESRD risk, and with rapid loss of kidney function.
MedicalResearch.com: What should readers take away from your report?
Response: Treatment of chronic insomnia could result in substantial benefits that go beyond subjective quality of life, and could affect among others renal outcomes.
MedicalResearch.com: What recommendations do you have for future research as a result of this study?
Response: Future studies are needed to determine which type of interventions to alleviate insomnia could efficiently improve clinical outcomes. Meanwhile, insomnia management should be part of routine renal care, especially for NDD-CKD patients.
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Citation: Abstract presented at the 2017 American Society of Nephrology
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