Our skin is subject to a multitude of internal and external influences that can affect its thickness and texture over time. Factors such as aging, environmental aggressors, lifestyle choices, and genetics can contribute to the gradual thinning and deterioration of skin quality. However, the good news is that there are various approaches to address these concerns and promote the restoration of skin thickness and texture.
In this article, we'll explore a few crucial factors that, according to research, play pivotal roles in this rejuvenation process.
The Proliferation and Migration of Skin Cells
According to the National Institutes of Health, at the core of skin thickness and texture restoration lies the process of cell proliferation and migration. The epidermis, the outermost layer of the skin, constantly undergoes renewal through a process known as epidermal turnover.
Stem cells within the basal layer of the epidermis divide and differentiate into keratinocytes. These gradually migrate upward to the skin's surface, replacing old, damaged cells.
According to Beyond CellCare, stem cell therapy differs from traditional treatments, which only target the symptoms of skin aging. By fostering cellular repair and renewal, it targets the fundamental mechanisms of aging.
Furthermore, certain skincare ingredients and treatments, such as chemical exfoliants and professional procedures like microdermabrasion and chemical peels, can accelerate cell turnover.
You’ll also find the use of exosome injection and similar therapy methods involving exosomes becoming popular in this regard. Exosomes facilitate skin cell proliferation and migration by transferring growth factors and signaling molecules.
(Please note that exosomes are currently not approved by the Food and Drug Administration (FDA) to treat or diagnose any disease).
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MedicalResearch.com Interview with:
Prof. Dr. Wolfram-Hubertus Zimmermann
Director, Institute of Pharmacology and Toxicology
University Medical Center Göttingen
Georg-August University
Göttingen, Germany
MedicalResearch.com: What is the background for this study?Response: Involvement in research and development in the field of tissue engineered heart repair since 25+ years.
Bench-to-bed translation of our research.
MedicalResearch.com: How are the stem cell obtained?Response: We make use of induced pluripotent stem cells as starting material to obtain heart muscle cells for the engineering of Engineered Human Myocardium (EHM) and its use as Biological Ventricular Assist Tissue (BioVAT).
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MedicalResearch.com Interview with:
Raymond M. Anchan, MD, Ph.D.
Director, Stem Cell Biology and Regenerative Medicine Research Laboratory
Assistant Professor, Harvard Medical School
Obstetrics/Gynecology
Center for Infertility and Reproductive Surgery
Brigham and Women's Hospital
MedicalResearch.com: What is the background for this study?Response: As a reproductive endocrinologist, I have the privilege of caring for patients who unfortunately experience premature ovarian insufficiency- Some of these patients are as young as 17 yo. Additionally, a significant number of patients over the years have been reproductive age women who have breast cancer and ovarian failure from chemotherapy. These patients have been my inspiration to try to find a treatment for them. Since my earlier days as a neurobiologist and stem cell scientist, it was a natural course for me to seek cell-based therapies that are patient specific using autologous iPSCs.
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MedicalResearch.com Interview with:
Gianluca Amadei PhD
Post-Doctoral Fellow
University of Cambridge, UK
MedicalResearch.com: What is the background for this study? What are the main findings?Response: The background of this study is that we tried to build a structure that looks and develops like a real mouse embryo using different kinds of mouse stem cells.
The main findings are that the resulting structures develop the entire embryonic body axis and the extraembryonic tissues that are required to support embryonic development. Our structures develop to a stage comparable to 8.5 days of embryonic development of the natural mouse embryos and have a brain and neural tube, a beating heart-like structure, gut and primordial germ cells.
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