AstraZeneca, Author Interviews, Diabetes, Kidney Disease / 24.06.2019
FARXIGA (dapagliflozin) Reduced Kidney Function Decline in Type II Diabetes
MedicalResearch.com Interview with:
Naeem Khan MD
Vice President at AstraZeneca
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: A pre-specified exploratory analysis of renal data from the DECLARE-TIMI 58 trial, the largest SGLT-2 inhibitor (SGLT-2i) cardiovascular outcomes trial (CVOT) conducted to date, showed that FARXIGA (dapagliflozin) reduced the composite of kidney function decline, end-stage renal disease (ESRD) or renal death by 47% in patients with type 2 diabetes (T2D).
Additionally, FARXIGA reduced the relative risk of a cardio-renal composite of kidney function decline, ESRD, or renal or cardiovascular (CV) death by 24% compared to placebo.
The analysis evaluated 17,160 patients with type 2 diabetes and predominantly preserved renal function, irrespective of underlying atherosclerotic CV disease (ASCVD).
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