06 Jun Urinary Biomarkers Identify Early Problems With Hip Replacements

MedicalResearch.com Interview with:

Dr. Sumner

Rick Sumner, PhD, FAAA
The Mary Lou Bell McGrew Presidential Professor for Medical Research
Chair, Department of Cell & Molecular Medicine (formerly, Anatomy and Cell Biology)
Rush University Medical Center
Chicago, IL  60612

MedicalResearch.com: What is the background for this study? What are the main findings?

Response: The main cause of failure for total hip replacements is implant loosening which is often a consequence of particle-induced peri-implant osteolysis. Unfortunately, this condition is usually not diagnosed until it has progressed to the point of needing a revision surgery.

We discovered two biomarkers that may be useful for identifying at risk patients much earlier than is currently possible.

MedicalResearch.com: What should readers take away from your report?

Response: Early identification of at-risk patients would alert surgeons to follow these patients more carefully and may suggest novel, non-surgical approaches to therapy.

MedicalResearch.com: What recommendations do you have for future research as a result of this study?

Response: The generalizability of the findings needs to be tested by studying additional cohorts of patients.

Disclosures: There is a provisional U.S. patent application on file.

Citation:
Ryan D. Ross, Youping Deng, Rui Fang, Nicholas B. Frisch, Joshua J. Jacobs, Dale R. Sumner.Discovery of biomarkers to identify peri-implant osteolysis before radiographic diagnosis. Journal of Orthopaedic Research®, 2018; DOI: 1002/jor.24044

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Last Updated on June 6, 2018 by Marie Benz MD FAAD