Bariatric Surgery Linked To Lower Long Term Mortality

David Arterburn, MD, MPH, FACP Associate Investigator Group Health Research Institute Seattle, WA 9810MedicalResearch.com Interview with:
David Arterburn, MD, MPH, FACP
Associate Investigator
Group Health Research Institute
Seattle, WA 98101   and

David L. Maciejewski PhD Center for Health Services Research in Primary Care Durham VA Medical Center, Durham, North CarolinaDavid L. Maciejewski PhD
Center for Health Services Research in Primary Care
Durham VA Medical Center, Durham, North Carolina

MedicalResearch.com: Why was this study needed?

Response: There were several reasons to conduct this study.  First, although complications and death during and soon after bariatric surgery have progressively declined over the past several decades, there is simply very little long-term evidence on the survival benefits of bariatric surgery in Americans having surgical procedures that are being used today in routine practice.

Second, we felt that it was important to look at the impact of bariatric surgery among veterans because they represent an older male cohort often with multiple medical comorbidities, which is different from the typical bariatric patient in the United States, who is often younger and female.

MedicalResearch.com: How was your study conducted?

Response: We conducted a retrospective observational study using high-quality data from national Department of Veterans Affairs electronic databases and the VA Surgical Quality Improvement Program. We identified veterans who underwent bariatric surgery in VA medical centers from 2000 to 2011. Three quarters of them were men. We matched them to control patients using an algorithm that included age, sex, VA geographic region, body mass index (BMI), diabetes, and Diagnostic Cost Group. We then compared survival across bariatric patients and matched controls using Kaplan-Meier estimators and stratified, adjusted Cox proportional hazards analyses

MedicalResearch.com: What were the main findings of your study?

Response: This study had three important results:

1)      Our analysis showed no significant association between bariatric surgery and death from all causes in the first year of follow-up. In other words, having bariatric surgery was not significantly related to a veteran’s chance of dying in the first year compared to not having surgery.

2)      We had an average follow-up of 6.9 years in the surgical group and 6.6 years in the matched control group. After one to five years, adjusted analyses showed significantly lower mortality in the patients who had surgery: 55% lower, with a hazard ratio of 0.45. The finding was similar at 5 or more years, with a hazard ratio of 0.47. This means that bariatric surgery was associated with lower long-term mortality – that is, better long-term survival among veterans, which is consistent with limited non-VA research that has addressed this same question.

3)      Finally, we also found that the relationship between surgery and survival were similar comparing men and women, patients with and without diagnosed diabetes, and patients who had bariatric surgery before versus after year 2006.

MedicalResearch.com: What should clinicians and patients take away from your report?

Response: The main implication of our study is that surgeons and patients with severe obesity can have greater confidence that bariatric surgical procedures are associated with better long-term survival than not having surgery. Prior studies have demonstrated this finding in younger, predominantly female population, but our study confirms this finding in an older, predominantly male cohort, with multiple comorbid health problems. Another important implication is that our study suggests that men and women, with and without diabetes, each have similar outcomes after bariatric surgery, although our findings should be examined more again in larger populations with longer-term follow-up.

MedicalResearch.com: What recommendations do you have for future research as a result of this study?

Response: More research is needed to understand the long-term impact of bariatric procedures on body weight, comorbid health conditions, and costs of care.  We have ongoing research to examine these issues. Further, there is very little long-term evidence on mental health and substance use outcomes of patients undergoing bariatric surgery, so we hope to obtain funding in the next year to address these questions.

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