Dietary Vitamin K Linked to Lower Heart Disease, Cancer Mortality Interview with
Mònica Bulló PhD
Human Nutrition Unit Department of Biochemistry & Biotechnology
IISPV  School of Medicine
Rovira i Virgili University
Sant Llorenç, Spain What are the main findings of the study?

Dr Bulló: There is some evidence that different dietary forms of vitamin K could exert varying effects on health, however no study to date has simultaneously evaluated the potential effects of the main vitamin K forms on cancer and cardiovascular mortality. We conducted a prospective, epidemiologic study involving 7,216 elderly subjects at high cardiovascular risk who were followed for about 5 years.The results of the present study show, for the first time that an increase in dietary intake of both forms of vitamin K is related to a lower risk of cardiovascular mortality, cancer mortality or all-cause mortality. Were any of the findings unexpected?

Dr Bulló: Our findings are not unexpected if we consider previous results of our group showing a beneficial effect of vitamin K on type 2 diabetes and inflammatory profile. However, highlight the potential role of vitamin k beyond the coagulation thus extending the pleiotropic role of the vitamin discovered by Dr Enrik Dam . What should clinicians and patients take away from your report?

Dr Bulló: Physicians should be aware of the potential role of vitamin K in chronic inflammatory diseases. However, our results should be interpreted cautious because to find correlation doesn’t always infer causality and additional confirmatory data is necessary. What recommendations do you have for future research as a result of this study?

Dr Bulló: Vitamin K emerges as a promising nutritional strategy in the prevention and/or progression of inflammatory chronic diseases. However, long-term intervention studies are needed to definitively confirm whether increased vitamin K intake can prolong life in this way and also the molecular mechanism underlying this beneficial role.


Dietary Intake of Vitamin K Is Inversely Associated with Mortality Risk J. Nutr. 2014 jn.113.187740; first published online March 19, 2014. doi:10.3945/jn.113.187740

Martí Juanola-Falgarona, Jordi Salas-Salvadó, Miguel Ángel Martínez-González, Dolores Corella, Ramón Estruch, Emili Ros, Montserrat Fitó, Fernando Arós, Enrique Gómez-Gracia, Miquel Fiol, José Lapetra, Josep Basora, Rosa María Lamuela-Raventós, Lluis Serra-Majem, Xavier Pintó, Miguel Ángel Muñoz, Valentina Ruiz-Gutiérrez, Joan Fernández-Ballart, and Mònica Bulló


Last Updated on March 25, 2014 by Marie Benz MD FAAD