13 Aug High Gluten Diet Adds to Risk of Celiac Disease in Genetically Predisposed Children
MedicalResearch.com Interview with:
Daniel Agardh MD PhD
Diabetes and Celiac Unit
Adjunct senior lecturer
MedicalResearch.com: What is the background for this study?
Response: Celiac disease is a common chronic small bowel disease caused by an intolerance against gluten in individuals carrying certain genes associated with celiac disease and type 1 diabetes. It is still unresolved why not all genetically at risk individuals that eat gluten develop celiac disease. It is been discussed for long if time to first exposure of gluten or high intake of gluten amounts may play a role, albeit with no uniform results.
The aim of this study was to investigate if gluten intake during the first 5 years of life affects the risk for developing celiac disease in children at genetic risk followed in four different countries in the prospective TEDDY study.
MedicalResearch.com: What are the main findings?
Response: The main findings showed that increased intake of gluten during the first 5 years of life is an independent risk factor for celiac disease autoimmunity and celiac disease in genetically predisposed children.
MedicalResearch.com: What should readers take away from your report?
Response: This study adds another piece to the celiac puzzle, i.e. what main risk factors are involved in the devolpment of celiac disease. We can now confirm that besides certain genes that also high intake of gluten amounts is important for the disease to develop.
MedicalResearch.com: What recommendations do you have for future research as a result of this work?
Response: Future research should focus on to identify if additional factors trigger celiac disease besides genes and gluten. By identifying those factors it will be possible to design intervention studies that test the hypothesis if celiac disease can be prevented.
Disclosures: I have a patent in collaboration with Probi AB, Lund, Sweden.
Andrén Aronsson C, Lee H, Hård af Segerstad EM, et al. Association of Gluten Intake During the First 5 Years of Life With Incidence of Celiac Disease Autoimmunity and Celiac Disease Among Children at Increased Risk. JAMA. 2019;322(6):514–523. doi:10.1001/jama.2019.10329
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