Study Finds No Link Between HPV Vaccine and Blood Clots Interview with:
Nikolai Madrid Scheller
Department of Epidemiology Research
Statens Serum Institut, Copenhagen

Medical Research: What are the main findings of the study?

Answer: In a large and comprehensive study of more than 1.5 million women including more than 500,000 HPV vaccinated there was no association between HPV vaccination and blood clots.

Medical Research: What should clinicians and patients take away from your report?

Answer: The HPV vaccines are now included in immunization programs around the world and emerging safety issues need to be addressed in thorough and well-designed studies to inform policymakers, caregivers, and the public. Our study adds to the body of data that support a favorable overall safety profile of the qHPV vaccine and expands this knowledge by providing comprehensive analyses of the risk of VTE after qHPV vaccination.

Medical Research: What recommendations do you have for future research as a result of this study?

Answer: It is essential that other severe adverse events reported in temporal association with HPV-vaccination are investigated in detail in controlled and well-powered studies to either confirm or refute an association with the vaccine in question, as earlier experiences have demonstrated that such safety concerns might compromise vaccine acceptance and uptake.


Scheller N, Pasternak B, Svanström H, Hviid A. Quadrivalent Human Papillomavirus Vaccine and the Risk of Venous Thromboembolism. JAMA. 2014;312(2):187-188. doi:10.1001/jama.2014.2198.


Last Updated on July 9, 2014 by Marie Benz MD FAAD