Dr. Moody

Scientists Discover Another Pathway of Allergic Contact Dermatitis

MedicalResearch.com Interview with:

Dr. D. Branch Moody, MD Principal Investigator Associate Physician, Brigham and Women's Hospital Professor of Medicine, Harvard Medical School

Dr. Moody

Dr. D. Branch Moody, MD
Principal Investigator
Associate Physician, Brigham and Women’s Hospital
Professor of Medicine, Harvard Medical School

MedicalResearch.com: What is the background for this study? Is the CD1a molecule found on the skin’s Langerhans cells?

Response: With increasing industrialization worldwide, people apply cosmetics and other consumer products to the skin, leading to contact dermatitis, which is becoming increasingly common. Immunologists know that T cells participate in dermatitis reactions. However, T cells usually recognize and respond to antigens that are peptides rather than the non-peptide antigens that cause contact dermatitis.

MedicalResearch.com: What are the main findings?

Response: In our study, we show that T cells can directly respond to non-peptidic antigens that cause contact dermatitis. We found that the response requires that the antigens bind to a protein called CD1a.

MedicalResearch.com: What should readers take away from your report?

Response: Understanding how antigens lead to immune response is the first step towards designing strategies to detect and block the response, which will likely be done in the future.

MedicalResearch.com: What recommendations do you have for future research as a result of this work? 

Response: We have recently started research with investigators in Oxford, UK, and Melbourne, Australia, to design blockers for the antigens that bind to CD1a. 


Science Immunology  03 Jan 2020:
Vol. 5, Issue 43, eaax5430
DOI: 10.1126/sciimmunol.aax5430


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Last Updated on January 5, 2020 by Marie Benz MD FAAD