“Coffee” by Treacle Tart is licensed under CC BY 2.0

Study Finds Protective Effect of Caffeine in Chronic Kidney Disease

MedicalResearch.com Interview with:

Coffee Wikipedia image

Wikipedia image

Miguel Bigotte Vieira  MD
Nephrology and Renal Transplantation Department
Centro Hospitalar Lisboa Norte
Lisbon, Portugal

MedicalResearch.com: What is the background for this study? What are the main findings?

Response: An inverse relationship between coffee consumption and mortality has been reported in the general population. However, the association between caffeine consumption and mortality in patients with chronic kidney disease (CKD) remains unclear. We examined the association between varying levels of caffeine consumption and mortality among 4863 patients with CKD in a prospective nationwide cohort, using the continuous National Health and Nutrition Examination Survey (NHANES) 1999-2010.

Our study showed a protective effect of caffeine consumption among patients with chronic kidney disease. The reduction in mortality was present even after considering other important factors such as age, gender, race, smoking, other diseases, and diet. 

MedicalResearch.com: What should readers take away from your report?

Response: Our study showed a dose-dependent protective effect of caffeine consumption on all-cause mortality among patients with CKD. These results suggest that advising patients with kidney disease to drink more caffeine may reduce their mortality. However, our observational study cannot prove that caffeine reduces the risk of death but only suggests the possibility of such a protective effect. This would represent a simple, clinically beneficial, and inexpensive option, though this benefit should ideally be confirmed in a randomized clinical trial.

MedicalResearch.com: What recommendations do you have for future research as a result of this work?

Response: Future research should focus on the benefits and harms of other compounds present in caffeine-containing beverages, and on the study of the association between caffeine consumption and mortality in other world regions.  

MedicalResearch.com: Is there anything else you would like to add? 

Response: This investigation resulted from teamwork of five investigators: Miguel Bigotte Vieira, Rita Magriço, Catarina Viegas Dias, Lia Leitão, João Sérgio Neves. No funding was received for the completion of this study.   

Citation: Miguel Bigotte Vieira, Rita Magriço, Catarina Viegas Dias, Lia Leitão, João Sérgio Neves; Caffeine consumption and mortality in chronic kidney disease: a nationally representative analysis, Nephrology Dialysis Transplantation, , gfy234, https://doi.org/10.1093/ndt/gfy234

[wysija_form id=”3″]



The information on MedicalResearch.com is provided for educational purposes only, and is in no way intended to diagnose, cure, or treat any medical or other condition. Always seek the advice of your physician or other qualified health and ask your doctor any questions you may have regarding a medical condition. In addition to all other limitations and disclaimers in this agreement, service provider and its third party providers disclaim any liability or loss in connection with the content provided on this website.


Last Updated on September 14, 2018 by Marie Benz MD FAAD