Lael S. Reinstatler, MD, MPH.PGY 4 Urology ResidencyDartmouth Hitchcock

HPV6 Serology Associated with Bladder Cancer Interview with:

Lael S. Reinstatler, MD, MPH.PGY 4 Urology ResidencyDartmouth Hitchcock

Dr. Reinstatler

Lael S
Reinstatler, MD, MPH.
PGY 4 Urology Residency
Dartmouth Hitchcock What is the background for this study? What are the main findings? 

Response: Human Papillomavirus is an oncogenic virus associated with other genitourinary cancers including penile cancer.

HPV is detectable in urine and in urethral swabs and it interacts with stratified squamous epithelium which lines the majority of the genitourinary tract. Prior research has identified HPV in bladder tumors but detection methods are inconsistent.

In this study, we looked for an association with HPV serology (indicating prior HPV systemic exposure) and bladder cancer. What should readers take away from your report? 

Response: The present study identified an association of positive HPV6 serology with bladder cancer. This may represent a different way of researching the possible link between HPV and bladder cancer and opens new doors for study. More information is needed including elucidating the oncogenic pathway, if any, that HPV may have in the urinary tract. As this was a large population-based analysis, the HPV6 association observed may be a marker for another unknown risk factor associated with bladder cancer. Future work is certainly warranted. What recommendations do you have for future research as a result of this work?

Response: We plan on extending this research into other cohorts. The current research is from a survey based study of US adults but more data is needed with other HPV subtypes and with specific stages and grades of bladder cancer.We have no disclosures.  


Reinstatler, Lael & Shee, Kevin & Stensland, Kristian & Dagrosa, Lawrence & Seigne, John & Sverrisson, Einar. (2019). MP05-12 RE-EXAMINING AN OLD TREND: THE ASSOCIATION OF HUMAN PAPILLOMAVIRUS AND BLADDER CANCER. Journal of Urology. 201. 10.1097/01.JU.0000554983.38815.b7.

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Last Updated on May 13, 2019 by Marie Benz MD FAAD