MedicalResearch.com Interview with:
Dr. Wataru Takayama
Tokyo Medical and Dental University
Department of Emergency and Disaster Medicine
MedicalResearch.com: What is the background for this study?
Response: ABO blood type is a potential risk of various diseases and various conditions. Furthermore, ABO blood type has a profound influence on hemostasis. Hemorrhage is the leading cause of death in patients with trauma, we assessed the association between the difference in blood types and the outcomes of death.
MedicalResearch.com: What are the main findings?
Response: Blood type O was the independent risk factor for all-cause in-hospital mortality and death due to exsanguination, TBI, and other causes after adjusting for potential confounders. This is the first study to report the association between ABO blood types and mortality in patients with severe trauma.
MedicalResearch.com: What should readers take away from your report?
Response: We cannot alter the risk of blood type O itself, but there is possibility the risk for bleeding depending on the differences in blood types.
If the mechanisms are true, clinical treatment for trauma is changeable.
Further study is needed, and we are now undergoing multi-center study.
MedicalResearch.com: What recommendations do you have for future research as a result of this study?
Response: The ABO antigens are expressed not only on the surface of RBCs but also on the surface of vascular endothelium. Emergency transfusion of RBCs with blood type O could influence hemostasis if the hemostatic mechanism is affected by the different surface antigens on RBCs. However, it is unclear how the difference in blood type affects the mechanism. Basic and translational research would be necessary to investigate the results of our study and develop a therapeutic strategy.
MedicalResearch.com: Thank you for your contribution to the MedicalResearch.com community.
Wataru Takayama, Akira Endo, Hazuki Koguchi, Momoko Sugimoto, Kiyoshi Murata, Yasuhiro Otomo. The impact of blood type O on mortality of severe trauma patients: a retrospective observational study. Critical Care, 2018; 22 (1) DOI: 10.1186/s13054-018-2022-0
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